ALPK2 Antibody

Code: CSB-PA006868

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Size:

50μg100μg

US$119

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Species Reactivity: Human

Raised in: Rabbit

Application: IHC, ELISA

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Target Background

Product Details

Uniprot NO.

Q86TB3

Target Names

ALPK2

Alternative Names

Alpha-protein kinase 2 antibody; ALPK2 antibody; ALPK2_HUMAN antibody; FLJ34875 antibody; FLJ43253 antibody; Gm549 antibody; HAK antibody; Heart alpha-protein kinase antibody; RGD1564431 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from the Internal region of Human Alpha-protein Kinase 2.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

IHC, ELISA

Protocols

Immunohistochemistry (IHC) Protocol ELISA Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling.

Gene References into Functions

Results showed that p.Q1853E variant of ALPK2, which had been accumulating in the Japanese population, induced a metastatic phenotype of colorectal tumors by disrupting ALPK2 function. PMID:28668886
ALPK2 is crucial for luminal apoptosis and expression of DNA repair-related genes, possibly in the transition of normal colonic crypt to adenoma. PMID:22641666

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Subcellular Location

Basolateral cell membrane.

Protein Families

Protein kinase superfamily, Alpha-type protein kinase family, ALPK subfamily

Tissue Specificity

Expressed in developing cardiac tissue and cardiomyocytes (at protein level).

Database Links

HGNC: 20565

UNIGENE: Hs.628152

KEGG: hsa:115701

STRING: 9606.ENSP00000354991