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Recombinant Human Epigen protein (EPGN), partial (Active)

Recombinant Human Epigen protein (EPGN), partial (Active)

CSB-AP002611HU

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US$142

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Express system: E.coli

Species: Homo sapiens (Human)

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Target Background

Product Details

Purity

>98% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU/μg as determined by LAL method.

Activity

Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 300 ng/ml, corresponding to a specific activity of >3.3x10³ IU/mg.

Uniprot NO.

Q6UW88

Research Area

Cancer

Alternative Names

ALGV3072; EPG; EPGN; EPGN_HUMAN; Epigen; Epigen precursor; Epithelial mitogen; PRO9904

Species

Homo sapiens (Human)

Source

E.coli

Expression Region

24-95aa

Target Protein Sequence

AVTVTPPITA QQADNIEGPI ALKFSHLCLE DHNSYCINGA CAFHHELEKA ICRCFTGYTG ERCEHLTLTS YA

Mol. Weight

7.9 kDa

Protein Length

Partial of Isoform 2

Tag Info

Tag-Free

Buffer

Lyophilized from a 0.2 µm filtered PBS, pH 7.4

Lead Time

5-10 business days

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

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Recombinant Human Epigen protein (EPGN), partial (Active)

Description

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Target Background

Function

Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.

Gene References into Functions

Study shows how the EGFR ligands epiregulin (EREG) and epigen (EPGN) stabilize different dimeric conformations of the EGFR extracellular region. Results reveal how responses to different EGFR ligands are defined by receptor dimerization strength and signaling dynamics. These findings have broad implications for understanding receptor tyrosine kinase (RTK) signaling specificity. PMID:28988771
cloning of a related gene in mouse PMID:112783
EPG is an EGF-like growth factor and a low affinity ligand PMID:15611079

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Subcellular Location

[Isoform 1]: Membrane; Single-pass type I membrane protein.; [Isoform 2]: Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.; [Isoform 4]: Secreted.; [Isoform 5]: Secreted.; [Isoform 6]: Secreted.

Database Links

HGNC: 17470

UNIGENE: Hs.401237

KEGG: hsa:255324

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