Human Complement 7,C7 ELISA Kit

Promotion

Code: CSB-E11167h-IS

Rate （N/A）
Review （0）

Compare

Size:

96T,5×96T,10×96T

Pls inquire

Quantity:

Sample Types: serum, plasma, tissue homogenates

Detect Range: 4.69ng/mL-300ng/mL

Sensitivity: 2.345ng/mL

Trial Size:

24T ELISA Kit Trial Size (Only USD$150/ kit)
* Sample kit cost can be deducted as a $30 credit for each 96-assay kit of the same analyte and brand you subsequently purchase within six months until depleted. More details >>

Interested in a trial size? Please leave a message below.

Send an Inquiry

Start an on-line Chat

Online ordering is currently available for U.S. customers only. For orders outside the U.S., please kindly submit an inquiry or start a chat with us.

Promotion

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Target Name

complement component 7

Alternative Names

C7 ELISA Kit; CO7_HUMAN ELISA Kit; complement component 7 ELISA Kit; Complement component C7 ELISA Kit

Abbreviation

Uniprot NO.

P10643

Species

Homo sapiens (Human)

Sample Type

serum, plasma, tissue homogenates

Detection Range

4.69ng/mL-300ng/mL

Sensitivity

2.345ng/mL

Assay Time

1-5h

Sample Loading Volume

50-100ul

Detection Wavelength

450 nm

Research Area

Immunology

Assay Principle

quantitative
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Measurement

Sandwich

Storage

Store at 2-8°C. Please refer to protocol.

Shelf Life

6 months

Lead Time

3-5 working days
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Troubleshooting and FAQs

ELISA kit FAQs

ELISA Data Analysis

ELISA Standard Curve & Curve Expert software

Description

This ELISA kit provides quantitative measurement of Complement 7 (C7) in human samples, supporting research into the membrane attack complex (MAC) and terminal complement pathway activation. Because C7 circulates at microgram-per-milliliter concentrations in healthy serum but shifts meaningfully during complement consumption or deficiency states, this kit is designed to capture both baseline and depleted levels with appropriate sample dilution.

Detection Range: The 4.69–300 ng/mL range requires dilution of serum and plasma samples, where normal C7 levels typically fall between 50–100 µg/mL. This built-in dilution step effectively minimizes matrix interference while still capturing the reduced C7 concentrations seen in complement consumption during bacteremia or immune complex disease.

Sensitivity: At 2.345 ng/mL, the kit detects C7 in diluted serum from individuals with hereditary C7 deficiency or in tissue homogenates where local complement production yields substantially lower concentrations than systemic circulation.

Sample Compatibility: Validation across serum, plasma, and tissue homogenates enables researchers to correlate systemic C7 levels with local hepatic or extrahepatic C7 expression, critical for studying tissue-specific complement biosynthesis.

Assay Efficiency: The 1–5 hour protocol and 50–100 µL sample volume accommodate longitudinal clinical cohort studies where serial blood draws and high-throughput plate processing are essential.

This kit is particularly suited for investigating meningococcal susceptibility in C7-deficient individuals, MAC-driven tissue injury, and complement biomarker profiling in systemic lupus erythematosus.

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor.

Gene References into Functions

this study shows that GG genotype of C7 provides protection against fibrosis severity while showing a higher risk for hepatocellular carcinoma in patients with hepatitis C PMID:29966690
Two case reports of C7 deficiency leading to recurrent meningitis and other bacterial infections are described. PMID:28078901
The complement C7 rs6876739 CC genotypes and mannan-binding lectin (MBL2) gene polymorphisms of liver donors were significantly associated with bacterial infection in recipients. PMID:27063552
Complement proteins C7 and CFH control the stemness of liver cancer cells via LSF-1 pathway. PMID:26723877
Borrelial CspA binds the human terminal complement components C7 and C9 and blocks assembly and membrane insertion of the terminal complement complex (TCC). PMID:23943762
Studies indicate that the deletion defect may be a more commonly distributed cause of C7 deficiency in Ireland. PMID:22206826
C7 isoelectric focusing variants can determine meningococcal killing in the early stage of infection when antibody-independent killing prevails. PMID:19931914
To determine transcriptional regulation of the human complement component C7, a 1 kb promoter fragment was cloned and the transcription start site was determined. C7 is expressed by the hepatoma-derived cell line Hep-3B, but not by Hep-G2. PMID:12595902
The interaction between the factor I domain of C7 and the C345C domain at the C terminus of the C5 alpha-chain plays an essential role in complement membrane attack complex formation and complement lytic activity. PMID:15879120
recurrence of fulminant meningococcal disease in a complement component C7-deficient patient PMID:15889368
membrane associated C7 acts as a trap for the late complement components to control excessive inflammation induced by SC5b-9 PMID:19179470
C7 is associated with multiple sclerosis pathogenesis. PMID:19221116
Data show that the two C7-FIMs pack closely together with an approximate 2-fold rotational symmetry that is rarely seen in module pairs and has not been observed in FD-containing proteins. PMID:19419965