UL111A Antibody

Code: CSB-PA517245ZA01HWW

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Size:

0.1ml

0.1ml1ml

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Species Reactivity: Human cytomegalovirus

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

F5HC71

Target Names

UL111A

Alternative Names

UL111A antibody; Viral interleukin-10 homolog antibody; cmvIL-10 antibody; vIL-10 antibody

Raised in

Rabbit

Species Reactivity

Human cytomegalovirus

Immunogen

Recombinant Human cytomegalovirus UL111A protein

Immunogen Species

Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (12-14 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

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Target Background

Function(From Uniprot)

Functional viral IL-10 homolog. Can bind to the human IL-10 receptor and compete with human IL-10 for binding sites. Requires both subunits of the human IL-10 receptor complex to induce signal transduction events and biological activities. IL-10 signaling pathway has several immunosuppressive activities that are exploited by the virus. Inhibits TLR-induced type I interferon production in host plasmacytoid dendritic cells.

Gene References into Functions

Authors show that the previously observed downregulation of hsa-miR-92a and upregulation of CCL8 during human cytomegalovirus latent infection of myeloid cells are intimately linked via the latency-associated expression of cytomegalovirus UL111A. PMID:25253336
These results suggest a significant and wide-ranging role for cmvIL-10 in the progression of breast cancer. PMID:24520416
cIL-10 expressing CD4 T-cells are directed against latently expressed US28 and UL111A. PMID:24130479
This study identifies a novel role for viral IL-10 in driving M2c polarization, which may limit virus clearance by restricting proinflammatory and CD4(+) T cell responses at sites of infection. PMID:23864618
CmvIL-10 bound avidly to the same receptors on blood mononuclear cells and was as bio-potent as native human IL-10. PMID:21402594