stau Antibody

Code: CSB-PA329523XA01DLU

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Size:

20μl50μl100μl

US$83

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Species Reactivity: Drosophila melanogaster (Fruit fly)

Application: ELISA, WB

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Product Details
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Target Background

Product Details

Uniprot NO.

P25159

Target Names

stau

Alternative Names

Maternal effect protein staufen stau CG5753

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) stau protein (321-582aa)

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA, WB

Protocols

ELISA Protocol Western Blotting(WB) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western Blot
Positive WB detected in: recombinant protein
All lanes: stau Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 34 kDa
Observed band size: 34 kDa

Description

To create the stau polyclonal antibody, a recombinant Drosophila melanogaster (Fruit fly) stau protein segment (321-582aa) is used as the immunogen to stimulate an antibody response in a rabbit. CUSABIO collects the rabbit serum and then purifies it using affinity chromatography to obtain the polyclonal antibodies against stau. The proficiency of the stau antibody in detecting the Drosophila melanogaster (Fruit fly) stau protein is confirmed through ELISA and WB assays, ensuring its effectiveness in experimental conditions.

The Staufen (Stau) protein in Drosophila melanogaster serves as a multifunctional regulator of RNA metabolism and cellular processes. Notably, Staufen plays a pivotal role in the localization of specific mRNAs, particularly in neurons, facilitating localized protein synthesis crucial for synaptic plasticity and neuronal development. Additionally, Staufen is involved in post-transcriptional gene regulation, impacting mRNA stability and translation, thus contributing to the overall control of protein levels in the cell. Furthermore, Staufen is implicated in cellular responses to environmental stress, such as heat stress, and has connections to the RNA interference pathway.

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Target Background

Function(From Uniprot)

RNA-binding protein which forms ribonucleoprotein complexes (RNPs) that play critical roles in the localization, translational repression and turnover of RNAs during embryogenesis, neurotransmission and neurogenesis. In the oocyte, essential for the localization of both the osk/oskar mRNA to the posterior pole and bcd/bicoid RNA to the anterior pole, and is therefore required for the correct anterior-posterior patterning of the developing embryo. Association with osk or bcd at their respective poles, appears to promote the formation and stabilization of the ribonucleoprotein complexes. Integral component of diverse neuritic ribonucleoprotein complexes (RNPs) that mediate the transport, translation and turnover of neuronal RNAs during neuorgenesis and the translation repression of synaptic transcripts in preparation for their dendritic targeting.

Gene References into Functions

The role of Miranda in the localization of Staufen during the division of neuroblasts is described. PMID:26423004
Staufen targets coracle mRNA to Drosophila neuromuscular junctions and regulates GluRIIA synaptic accumulation and bouton number. PMID:24951879
establishment of developmental precision and proportions in the early Drosophila embryo PMID:11845210
role in long-term memory PMID:12593794
Miranda has a role in coupling oskar mRNA/Staufen complexes to the bicoid mRNA localization pathway PMID:16905128