Made-to-order (12-14 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Value-added Deliverables
① 200ug * antigen (positive control); ② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection; ② ELISA titer can be guaranteed 1: 64,000; ③ WB validation with antigen can be guaranteed positive;
Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes.
Gene References into Functions
Resistin inhibited the activation of CREB, resulting in suppression of PGC-1alpha. Importantly, overexpressing PGC-1alpha can rescue the inhibitory effects of resistin on fatty acid beta oxidation.PMID:29730652
Resistin-associated VSMC dysfunction and intimal hyperplasia are related to PKCepsilon-dependent Nox activation and ROS generationPMID:27573736
OLI is a physiological repressor of systemic resistin release whereas FFA upregulate resistin release in vitro from adipocytes.PMID:26285069
Resistin possibly acts via an intracrine pathway as an intracellular sensor, regulating the adipocyte insulin sensitivity.PMID:26036220
Mouse Resistin has regulative effects on murine bone marrow hematopoiesis.PMID:26572487
murine resistin is increased in the lungs of wild-type mice following acute ozone exposure but does not promote ozone-induced lung pathology.PMID:26386120
Inhibition of miR-696 restored the triglycerides content by up to 80%, which suggests that, in C2C12 cells, resistin at least partially increases the deposition of lipids through miR-696.PMID:25962325
Antiresistin RNA oligo ameliorated metabolic abnormalities and histopathology of nonalcoholic fatty liver disease through attenuating proinflammatory cytokinesPMID:25922835
Resistin regulates PAI-1 expression in 3T3-L1 adipocytes via Akt phosphorylation.PMID:24667608
Oxidized-LDL promotes the expression and secretion of visfatin and resistin through its activation of endoplasmic reticulum stress.PMID:24278099
ET type-A receptor, ERK1/2, JNKs, AKT, and JAK2, but not ET type-B receptor or p38, are necessary for the ET-1 stimulation of resistin gene expressionPMID:24424064
resistin is a negative regulator of SIRT1 in both human hepatoma cell line HepG2 and mouse hepatocytes.PMID:23827175
Both resistin gene expression and its secretion from the epididymal adipose tissue were decreased in db/db obese mice, while the insulin-sensitizing drug rosiglitazone increased resistin production.PMID:23776497
lipid content was significantly decreased in 3T3-L1 cells transfected with anti-resistin small interfering RNA (siRNA) after adipocyte differentiationPMID:24034627
The effect between resistin and adiponectin on the proliferation of vascular smooth muscle cells (VSMCs), was investigated.PMID:23267839
The current study was initiated to determine whether resistin has additional roles in glucose-dependent insulinotropic polypeptide -regulated adipocyte functions.PMID:23002036
significant changes in fasting-induced adipose factor (FIAF), resistin (Rstn), long-form leptin receptor (LepRb) and suppressor of cytokine-3 (SOCS3) gene expression following chronic SCI and with advanced agePMID:22815920
results identify resistin as a potential inhibitory ligand for the receptor ROR1 and demonstrate, for the first time, that ROR1 plays an important role in adipogenesis and glucose homeostasis in 3T3-L1 cellsand glucose homeostasis in 3T3-L1 cells.PMID:22074948
Cleavage product of decorin serves as a functional receptor of resistin in adipocyte progenitors and may regulate white adipose tissue expansion.PMID:21683670
review of evidence that resistin (secreted by adipocytes in the mouse) is an inflammatory biomarker and a potential mediator of obesity, diabetes and cardiovascular disease [REVIEW]PMID:21497511
Valsartan did not alter resistin expression in the ob/ob mouse.PMID:20472602
Data suggest that s-resistin isoform may play a role in inflammatory processes.PMID:20627112
data suggest that endogenous resistin might be capable of fine-tuning the expression and enzymatic activity of various hypothalamic targets previously implicated in the delicate homeostatic control of food intakePMID:19646421
Tumor necrosis factor alpha is a negative regulator of resistin gene expression and secretion in 3T3-L1 adipocytesPMID:11689013
Mechanisms regulating adipocyte expression of resistinPMID:11901161
examined the effect on resistin expression of various hormones and cytokines known to affect insulin sensitivity.PMID:12031960
Data demonstrate that basal and hormonal stimulation of resistin secretion by insulin is inhibited by ET-1.PMID:12163029
results indicate that the substantial reduction of adiposity in lactation does not lead to any changes in resistin gene expression in white adipose tissuePMID:12163041
expression and regulation in mouse pituitary; data suggest that local resistin expression could have functional implications during prepubertal maturation of the hypothalamic-pituitary systemPMID:12208498
during in vivo bone formation and remodeling, probably acting as a co-factor or accessory protein that modulates the effects of primary signaling moleculesPMID:12413946
Resistin expression is regulated by C-EBP Proteins, peroxisome proliferator-activated receptor, and signal-transducing molecules.PMID:12437985
Resistin is regulated and expressed in mouse brown adipocytesPMID:12482590
resistin does not alter insulin receptor signaling but does affect insulin-stimulated glucose uptake, presumably by decreasing the intrinsic activity of cell surface glucose transportersPMID:12618360
ADSF/resistin secretion controls fat cell differentiation and adipose tissue development.PMID:12660879
Despite severe weight loss and significant falls in leptin expression and insulin concentration, resistin gene expression appears unchanged in white adipose tissue of mice with MAC16 tumour.PMID:12660881
Data show that neuropeptie Y significantly increased resistin mRNA expression in white adipose tissue compared with artificial cerebrospinal fluid treated controls.PMID:12684710
resistin is a novel secreted factor first identified as a TZD-suppressible genePMID:12700889
results demonstrate that leptin decreases resistin expression and suggest that resistin may influence glucose homeostasisPMID:14962997
mice lacking resistin exhibit low blood glucose levels after fasting, due to reduced hepatic glucose production; data support a physiological function for resistin in the maintenance of blood glucose during fastingPMID:14976316
Inhibits insulin-stimulaed glucose uptake into skeletal muscle cells without affecting insulin signaling pathways. Review.PMID:15055467
demonstrates in vivo the inhibitory role of ADSF in adipogenesisPMID:15090646
Pituitary resistin expression is age- and gender-dependent. In ob/ob and fasted mice, resistin is regulated in a tissue-specific manner. Visceral fat obesity increases but starvation decreases resistin mRNA.PMID:15103228
Plasma resistin of leptin-treated mice was barely decreased.PMID:15126241
Chronic hyperresistinemia impairs normal glucose metabolism.PMID:15189975
Nutritional regulation of resistin and changes in resistin gene expression and circulating levels in obesity are mediated, at least in part, through insulin and glucose.PMID:15220189
results indicate that chronic "hyper-resistinemia" leads to whole-body insulin resistance involving impaired insulin signaling in skeletal muscle, liver, and adipose tissue, resulting in glucose intolerance, hyperinsulinemia, and hypertriglyceridemiaPMID:15254589
These results provide strong support for a physiological role of resistin in the development of hepatic insulin resistance.PMID:15254590
Article reviews recent studies of Resistin/ADSF/FIZZ3 in transgenic and knockout mice.PMID:15358276
Resistin overexpression induces dyslipidemia in mice, which is commonly seen in the insulin-resistant state, partially through enhanced secretion of lipoproteins.PMID:15471967
gender differences in resistin, adiponectin and leptin mRNA expression and plasma levels were not ablated by castration and seem to be dependent on other factors in addition to gonadal steroidsPMID:15483213
Show
More
Hide
All
Subcellular Location
Secreted.
Protein Families
Resistin/FIZZ family
Tissue Specificity
Expressed in white but not brown adipose tissue in a variety of organs.