pot1 Antibody

Code: CSB-PA018382XA01SXV

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0.1ml

0.1ml1ml

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Species Reactivity: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

O13988

Target Names

pot1

Alternative Names

pot1 antibody; SPAC26H5.06 antibody; Protection of telomeres protein 1 antibody

Raised in

Rabbit

Species Reactivity

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Immunogen

Recombinant Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) pot1 protein

Immunogen Species

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Datasheet & COA

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Target Background

Function(From Uniprot)

Single-stranded telomeric DNA-binding protein that is required to protect the 3'-end telomeric overhang. It binds the consensus sequence 5'-GGTTAC-3'. Regulates telomerase and telomere length.

Gene References into Functions

Thus, our results suggest that pik1(+) is required for the maintenance of circular chromosomes. PMID:29410177
The Pot1 DNA-binding domain is capable of binding DNA in at least two structurally distinct binding modes. PMID:25074378
Pot1 promiscuity is implemented through binding modes that thermodynamically compensate for base-substitutions through alternate stacking interactions and hydrogen-bonding networks. PMID:23201273
Results indicate an unanticipated ssDNA-binding mode in which two SpPot1 molecules bind an oligonucleotide containing two telomeric repeats. PMID:21911358
The high affinity conserved DNA-binding activity of Pot1 protein is conferred by a DNA-binding domain consisting of two subdomains. PMID:21815629
The Pot1 (protection of telomeres) protein prevents access of telomerase to the 3'-ends of telomeres and protects telomeric DNA against exonucleolytic degradation. [pot1] PMID:15637058
Pot1(1-389) presents a new model for studying and understanding the ssDNA-binding activity of S. pombe Pot1 and illustrates the malleability of both the ssDNA ligand and the oligosaccharidce-binding fold in the recognition and binding of telomeric ssDNA. PMID:16842820
Considering that the antiparallel tetraplex inhibits telomerase-mediated telomere elongation, we conclude that the ability of Pot1 to unfold the antiparallel tetraplex is required for telomerase-mediated telomere regulation. PMID:17158862
Characterization of the thermodynamics and accommodation of both cognate and noncognate telomeric single-stranded DNA (ssDNA) sequences by Pot1pN, an autonomous ssDNA-binding domain (residues 1-187) found in full-length S. pombe Pot1. PMID:18355038
study shows Tpz1 forms a complex with Pot1; Tpz1 binds to Ccq1 & Poz1 which protect telomeres redundantly & regulate telomerase in positive & negative manners; thus, Pot1-Tpz1 complex accomplishes its functions by recruiting effector molecules Ccq1 & Poz1 PMID:18535244
model in which conformational selection and induced fit play important roles in the recognition of ssDNA by Pot1pN (residues 1-187 of full-length Pot1) PMID:19232358