Oxt Antibody

1. The abnormal social behaviors of Dio3-/- mice were associated with sexually dimorphic alterations in the physiology of oxytocin (OXT) and arginine vasopressin (AVP), 2 neuropeptides with important roles in determining social interactions. PMID:28715127
2. Data indicate that oxytocin participates in the spine remodeling, synaptic refinement, and social stimuli-dependent plasticity in the posterodorsal medial amygdala of male mice. PMID:28889007
3. Activation of the oxytocin receptor in brain regions facilitates social defeat posture. PMID:29186377
4. the absence of OT leads to significant changes in the expression of the studied genes (OTR, ERalpha, ERbeta, V1aR), and these changes may contribute to the decreased sexual behavior observed in OT gene knockout females. PMID:27558735
5. These results reveal that Oxt protects pancreatic beta cells against death caused by metabolic stress, and Oxt signaling may be a potential therapeutic target. PMID:27143105
6. CA3 pyramidal cells in the adult mouse hippocampus express OXT receptors and receive inputs from hypothalamic OXT neurons. PMID:28912554
7. These results identify G9a-induced histone methylation at the OXT and AVP promoters in the Basolateral Amygdala as a mechanism for mediating stress-induced lasting behavioral depression and its reversal by exercise. PMID:25863961
8. Data indicate that oxytocin is an important synaptic modulator in the posterodorsal medial amygdala, a finding that is likely involved with the display of the female sexual behavior. PMID:26163772
9. OXT was up-regulated in both hypothalamic magnocellular neurosecretory cells and parvocellular cells by chronic inflammation, and also that OXT in the PVN-spinal pathway may be involved in sensory modulation PMID:25943916
10. role for a neuronal population in the control of maternal care and oxytocin secretion; and evidence for a causal relationship between sexual dimorphism in the adult brain and sex differences in parental behaviour PMID:26375004
11. Oxtr signaling is crucial for entrainment of odor to social cues but is dispensable for entrainment to nonsocial cues. Oxt conveys saliency of social stimuli to sensory representations in the piriform cortex during odor-driven social learning. PMID:26139372
12. Oxytocin is is required for proper muscle tissue regeneration and homeostasis, and that plasma levels of oxytocin decline with age. Genetic lack of oxytocin does not cause a developmental defect in muscle but instead leads to premature sarcopenia. PMID:24915299
13. results describe fundamental synaptic mechanisms by which oxytocin increases the salience of acoustic social stimuli; furthermore, oxytocin-induced plasticity provides a biological basis for lateralization of auditory cortical processing PMID:25874674
14. Results show that OT inhibits appetite for carbohydrates; sucrose consumption considerably enhances OT gene expression and is particularly sensitive to OT receptor blockade PMID:24893201
15. Data suggest that oxytocin plays a crucial role in the sexual behavior display, number of released oocytes and density of dendritic spines in the MePD of female mice without affecting AVP plasma concentration PMID:23906766
16. lactic acid microbes accelerate wound healing via the neuropeptide hormone oxytocin PMID:24205344
17. CD38 in the nucleus accumbens and oxytocin are critical in paternal behavior. PMID:24059452
18. A new form of plasticity is identified in neonatal mice, when early sensory experience cross-modally regulates development of all sensory cortices via oxytocin signaling. PMID:24464043
19. the rewarding properties of social interaction in mice require the coordinated activity of oxytocin and 5-HT in the nucleus accumbens--with implications for understanding the pathogenesis of social dysfunction in neuropsychiatric disorders like autism PMID:24025838
20. data suggest that OT modulates social investigation behavior and the aggressiveness of male mice. T PMID:23376700
21. Oxytocin pathways may not be essential for regulating voluntary sodium ingestion. PMID:22784207
22. medial amygdala likely modulates hostile aggressive behavior associated with immediate early gene expression in OXT and vasopressin neurons PMID:23403283
23. these results support the hypothesis that the expression of the mouse oxytocin receptor gene is epigenetically regulated by DNA methylation of its promoter. PMID:23441222
24. We conclude that Maged1 is required for oxytocin processing or stability. A decrease in mature OT levels in Maged1 mutants affects social interactions and possibly other behavioral processes PMID:22865874
25. OT release in bone marrow by a rising estrogen concentration may facilitate rapid skeletal recovery during the latter phases of lactation. PMID:22761429
26. We consider hypotheses of the roles played by central and systemic OT release as well as their control and modulation in the female in mating and pregnancy--REVIEW PMID:22107910
27. we describe data detailing the molecular mechanism of CD38-dependent OXT secretion in CD38 knockout mice--REVIEW PMID:22227279
28. results support the idea that variation in ovarian hormones could be related to individual differences in social recognition, at least partly through modulation of the OT and/or AVP systems, particularly in the DS, LA and MPOA. PMID:22079582
29. The data suggested that vasopressin or oxytocin exert a minimal effect on most GABA neurons in the lateral hypothalamus but exert a robust excitatory effect on presumptive GABA cells that contain melanin-concentrating hormone. PMID:22262306
30. there is a local feed-forward loop in bone marrow through which the OT so produced from osteoblasts in response to estrogen acts upon its receptor to exert a potent anabolic action. PMID:21741363
31. Oxytocin plays a pivotal role in mediating the adaptation mechanism following chronic homotypic stress in mice. PMID:21439349
32. Fto, a proposed transcription co-factor, influences expression of the gene encoding a satiety mediator, oxytocin. PMID:21514276
33. Recently a new tool has been created that has furthered our understanding of oxytocin's role in behavior: transgenic mice that lack either the ability to synthesize oxytocin or the oxytocin receptor itself--REVIEW PMID:20732312
34. global reduction in FGF8 signaling leads to an overall reduction of mature OT and oxyphysin prohormone levels that may have resulted from defects in multiple stages of the hormone-synthesis pathway PMID:21046478
35. central oxytocin plays a pivotal role in mediating the adaptation mechanism following repeated restraint stress in mice PMID:20969650
36. Oxytocin acts as a carbohydrate-specific inhibitor of feeding. PMID:20685878
37. OXT elicits Ca2+ signals via OXTR in murine taste buds PMID:20700536
38. Data show that EBs expressed Oct-4, OTR, OT, and DAZL. PMID:19695304
39. The upregulation of central oxytocin expression is involved in mediating the adaptation mechanism following chronic repeated stress in mice. PMID:19889866
40. oxytocin mediates stress-induced analgesia PMID:11956346
41. The OT/OTR system plays an important role in cardiogenesis by promoting cardiomyocyte differentiation. PMID:12093924
42. Results suggest that estrogen receptor-beta activation may play a critical role in estrogenic regulation of oxytocin and arginine vasopressin gene expression in the paraventricular nucleus. PMID:12531518
43. OT is 1)involved in tonic blood pressure maintenance; 2)extends the functional range of arterial baroreceptor reflex; 3)reduces the sympathetic reserve PMID:12531722
44. required for mammalian social recognition, through which an individual learns to recognize other individuals PMID:12730370
45. that OT pathways play a role in modulating anxiety in female mice of the C57BL/6 background, and the effect is mediated by the OT receptor. PMID:12746288
46. oestrogen-dependent regulation of oxytocin and vasopressin synthesis in the paraventricular hypothalamic nucleus is mediated by ERbeta. PMID:12834440
47. Blood oxytocin concentrations on d 9 postpartum were also lower in Usf2-/- mice than Usf2+/+ mice PMID:12907752
48. Regulatory element in the intergenic region of the oxytocin gene controls hypothalamus-specific expression. PMID:12944509
49. Oxytocin plays a role in the regulation of blood pressure and salt appetite. PMID:12953013
50. OT signaling pathways are unnecessary for the anorexigenic effects of systemically administered CCK and d-fenfluramine in C57BL/6 mice. PMID:14557235

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UNIGENE: Mm.16745

KEGG: mmu:18429

STRING: 10090.ENSMUSP00000028764