Madcam1 Antibody

Code: CSB-PA013308ZA01RA

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Size:

0.1ml

0.1ml1ml

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Species Reactivity: Rattus norvegicus

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

O70540

Target Names

Madcam1

Alternative Names

Madcam1Mucosal addressin cell adhesion molecule 1 antibody; MAdCAM-1 antibody; rMAdCAM-1 antibody

Raised in

Rabbit

Species Reactivity

Rattus norvegicus

Immunogen

Recombinant Rattus norvegicus Madcam1 protein

Immunogen Species

Rattus norvegicus (Rat)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (12-14 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

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Target Background

Function(From Uniprot)

Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both the integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes.

Gene References into Functions

Immunohistochemical analysis of MAdCAM-1 expression during acute rejection on small bowel grafts in rats PMID:12034298
Treatment with an antibody to this antigen reduces glomerular and tubulointerstitial scarring in a rat model of crescentic glomerulonephritis PMID:12368200
Our model of chronic food allergy revealed that lymphocyte migration was increased with MAdCAM-1 upregulation. PMID:14670821
During small bowel allograft rejection., FTY720 was found to prevent the down-regulation of MAdCAM-1 expression in endothelial venules PMID:16387148