gsk-3 Antibody

Code: CSB-PA886973XA01CXY

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Size:

0.1ml

0.1ml1ml

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Species Reactivity: Caenorhabditis elegans

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

Q9U2Q9

Target Names

gsk-3

Alternative Names

gsk-3 antibody; sgg-1 antibody; Y18D10A.5Glycogen synthase kinase-3 antibody; EC 2.7.11.26 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans gsk-3 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Datasheet & COA

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Target Background

Function(From Uniprot)

Phosphorylates oma-1, a regulator of the oocyte-to-embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibiting mesoderm development. Required for normal lifespan and LiCl-induced lifespan extension.

Gene References into Functions

In C. elegans germline stem cells, loss of gsk-3 results in reduced germline stem cell proliferation without changes in differentiation or responsiveness to GLP-1/Notch signaling. PMID:29695611
Rearrangement of mitotic spindles requires the GSK-3 kinase. Apoptotic cell clearance and migration of the distal tip cell require the GSK-3 kinase. PMID:20126385
(i) GSK-3 inhibits SKN-1 activity in the intestine, (ii) the phase II response integrates multiple regulatory signals, and (iii), by inhibiting this response, GSK-3 may influence redox conditions. PMID:16251270
GSK3 converts OMA-1 and OMA-2 from being key regulators of oocyte maturation to key regulators of 1-cell embryo development PMID:16289132