ELISA Kits for Tumor Marker Research
Tumor markers (TM), produced by cancer cells or other cells, are a group of substances that reflect cancer-related information. They play important roles in early cancer screening, assisting in diagnosis, observing treatment efficacy, monitoring recurrence, and evaluating prognosis. An ideal tumor marker should possess high specificity, strong sensitivity, good stability, easy detection, and close clinical relevance. In recent years, with the development of precision medicine, tumor markers have gained increasing attention. Expanding our understanding of tumor markers can provide more references and support for gaining insights into the mechanisms of tumor development, clinical theories related to diagnosis and treatment, and further exploration of novel tumor markers.
CUSABIO is committed to providing researchers with highly accurate and sensitive tumor marker ELISA kits. These kits cover a variety of common tumor markers such as ACTH, AFP, CEA, hCG, CA 15-3, CA 19-9, CA125, NSE, and more. They enable rapid and quantitative detection of specific tumor markers, facilitating in-depth research into the molecular mechanisms of malignant tumor development and exploration of new tumor treatment strategies. Our kits provide precise and reliable data support for your scientific research, helping you achieve breakthroughs in the field of oncology.
1.Overview of Tumor Markers
1.1 What Are Tumor Markers?
Tumor marker refers to any substance produced by cancer cells or normal (non-cancer) cells in response to cancer in organisms. In the traditional sense, tumor markers refer to protein or other substances produced by cancer cells. These markers are high in content and can be detected in blood, urine, feces, tumor tissues or other tissues and body fluids of some cancer patients. In addition, gene expression patterns and DNA changes (such as mutations and other changes) can also be used as tumor markers. The results of tumor markers are not usually used for diagnosis alone, but combined with clinical symptoms and imaging research can provide clues for the diagnosis and treatment of cancer.
Some tumor markers provide information about only one specific type of cancer, while others provide information about more than one cancer.
1.2 Why Perform Tumor Marker Testing?
Cancer screening: Screening for cancer in people with a specific family history of cancer but no symptoms.
Help diagnose cancer: Tumor markers can not be used to diagnose cancer alone, but are usually combined with the results of other tests (such as biopsy or imaging) to diagnose cancer.
Monitor cancer progress and treatment efficacy: Cancer progress can also be monitored by measuring tumor markers regularly during cancer treatment. For example, a decrease in the level of tumor markers may indicate that the treatment is working, and vice versa.
Monitor for cancer recurrence: For some cancers, the increase of specific tumor markers may indicate cancer recurrence after surgery.
Determine the extent of cancer spread (staging): Tumor markers may help to determine the staging of cancer, which is very important for choosing the best treatment plan.
Estimating prognosis: Verifying the therapeutic effect.
1.3 Common Tumor Markers
According to different molecular types, tumor markers can be divided into:
(1) Enzyme or isoenzyme (PSA, PAP, NSE)
(2) Hormones (hCG, ACTH)
(3) Tumor embryonic antigen (AFP, CEA)
(4) Carbohydrates (CA 15-3, CA 19-9, CA125)
(5) Genes (BRCA1, K-ras)
The table below summarizes some common tumor markers that are closely related to various cancers:
| Tumor maker |
Cancer types |
Use with Cancer |
| Alpha-fetoprotein (AFP) |
Liver cancer, ovarian cancer and testicular cancer |
help diagnose cancer;
help stage a cancer;
monitor cancer progress and treatment efficacy;
monitor for cancer recurrence |
| Beta-2-microglobulin (B2M) |
Multiple myeloma, chronic lymphocytic leukemia, and some lymphomas |
monitor cancer progress and treatment efficacy;
estimate prognosis |
| Carcinoembryonic antigen (CEA) |
Colorectal cancer, lung cancer, gastric cancer, thyroid cancer, pancreatic cancer, breast cancer, and ovarian cancer |
monitor cancer progress and treatment efficacy;
monitor for cancer recurrence |
| CA-125 |
Ovarian cancer |
help diagnose cancer;
monitor cancer progress and treatment efficacy;
monitor for cancer recurrence |
| CA 15-3 and CA 27-29 |
Breast cancer |
monitor cancer progress and treatment efficacy;
monitor for cancer recurrence |
| CA 19-9 |
Pancreas cancer, gallbladder cancer, cholangiocarcinoma, and gastric cancer |
monitor cancer progress and treatment efficacy |
| Prostate-specific antigen (PSA) |
Prostate cancer |
help diagnose cancer;
monitor cancer progress and treatment efficacy;
monitor for cancer recurrence |
| Thyroglobulin |
Thyroid cancer |
monitor cancer progress and treatment efficacy;
monitor for cancer recurrence |
For more detailed information about tumor markers, please click: /c-20631.html
2. Importance of ELISA in Detection of Tumor Markers
ELISA (Enzyme-Linked Immunosorbent Assay) is a commonly used immunological detection technique that can be employed to detect specific proteins, antibodies, or other molecules in various biological samples. In the context of tumor marker detection, ELISA technology is widely applied and its importance is evident in the following aspects:
- High sensitivity and specificity: ELISA technology exhibits high sensitivity and specificity in the detection of tumor markers. It can detect very low concentrations of markers while avoiding interference from other substances, thereby providing a fast, accurate, and reliable method for tumor marker detection.
- Diverse sample types: ELISA technology can be applied to detect tumor markers in samples such as serum, plasma, cell culture supernatant, tissue homogenates, etc., accommodating the diverse biological distribution characteristics of different tumor markers.
- Quantitative and semi-quantitative analysis: ELISA technology enables the quantitative measurement of tumor marker concentrations, aiding researchers in understanding the expression levels of markers under different conditions. It can also be used for semi-quantitative analysis, facilitating the comparison of relative differences between samples.
- High throughput and ease of operation: ELISA technology is characterized by its simplicity, allowing for the simultaneous detection of multiple samples and enhancing experimental efficiency.
- Disease research and mechanistic insights: ELISA technology plays a crucial role in unraveling the mechanisms of tumor development and investigating the associations between markers and diseases. It provides researchers with a valuable tool for gaining in-depth understanding of tumor biology.
3.CUSABIO Tumor Marker ELISA Kits
