ZG16B

ZG16B, the zymogen granule protein 16 homolog B, pancreatic adenocarcinoma up-regulated factor, alias PAUF, JCLN2, HRPE773, PRO1567. ZG16B is a mammalian lectin containing a p-prism structure with the ability to regulate cell adhesion, metastasis, apoptosis, angiogenesis, and cell-cell interactions to recognize pathogens.
The mechanism of action of ZG16B involves the activation of multiple signaling pathways, such as CXCR4, β-catenin, TPL2/MEK/ERK, FAK/Scr, etc., to promote tumor cell migration and angiogenesis.
ZG16B is abnormally expressed in a variety of tumors, especially highly expressed in pancreatic cancer, and plays an important role in tumor cell proliferation, adhesion, migration, and invasion, making it a potential tumor diagnostic biomarker and therapeutic target. Currently, several antibodies against ZG16B are in the clinical stage, mainly used in the treatment of pancreatic cancer and ovarian cancer, showing its potential and importance in tumor therapy.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human ZG16B at 2 μg/ml can bind Anti-ZG16B recombinant antibody (CSB-RA836195MA1HU), the EC₅₀ is 24.13-46.04 ng/mL.

The purity of ZG16B was greater than 95% as determined by SEC-HPLC

Recombinant Macaca fascicularis zymogen granule protein 16 homolog B (ZG16B) (Active)(CSB-MP4727MOV)

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis ZG16B at 2μg/mL can bind Anti-ZG16B recombinant antibody (CSB-RA836195MA1HU)， the EC₅₀ is 20.15-28.98 ng/mL.

ZG16B Recombinant Monoclonal Antibody(CSB-RA836195MA1HU)

Validated Data

The Binding Activity of Human ZG16B with Anti-ZG16B recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ZG16B (CSB-MP836195HU) at 2 μg/mL can bind Anti-ZG16B recombinant antibody, the EC₅₀ is 24.13-46.04 ng/mL.

The Binding Activity of Macaca fascicularis ZG16B with Anti-ZG16B recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis ZG16B (CSB-MP4727MOV) at 2 μg/mL can bind Anti-ZG16B recombinant antibody , the EC₅₀ is 20.15-28.98 ng/mL.

The following ZG16B reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

ZG16B Antibodies

ZG16B Proteins

ZG16B Antibodies

ZG16B Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-RA836195MA1HU	ZG16B Recombinant Monoclonal Antibody	Human, Macaca fascicularis	ELISA
CSB-PA836195ZA01HU	ZG16B Antibody	Homo sapiens	ELISA, WB (ensure identification of antigen)
CSB-RA836195MB2HU	ZG16B (Ulenistamab Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA836195MB1HU	ZG16B (US20200055951A1 Biosimilar) Recombinant Monoclonal Antibody	Human

ZG16B Proteins

ZG16B Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Code	Product Name	Source
CSB-MP4727MOV	Recombinant Macaca fascicularis zymogen granule protein 16 homolog B (ZG16B) (Active)	Mammalian cell

ZG16B Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP836195HU	Recombinant Human Pancreatic adenocarcinoma up-regulated factor (ZG16B)	Yeast
CSB-EP836195HU	Recombinant Human Pancreatic adenocarcinoma up-regulated factor (ZG16B)	E.coli
CSB-MP836195HU	Recombinant Human Pancreatic adenocarcinoma up-regulated factor (ZG16B) (Active)	Mammalian cell
CSB-MP836195HUd9	Recombinant Human Pancreatic adenocarcinoma up-regulated factor (ZG16B)	Mammalian cell

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ZG16B

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