TNFR1

TNFR1 (Tumor Necrosis Factor Receptor 1), also known as TNF-R55 or CD120a, is a receptor protein that interacts with Tumor Necrosis Factor-Alpha (TNF-α) and plays a crucial role in various physiological and pathological processes. It consists of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain binds to TNF-α, triggering signal transduction. The intracellular domain contains a Death Domain, which plays a critical role in initiating apoptosis (cell self-destruction) and other cell signaling pathways.

TNFR1 primarily mediates various biological effects through its interaction with its ligand, TNF-α. When TNF-α binds to TNFR1, it initiates a series of signal transduction events, including the activation of NF-κB (Nuclear Factor-κB) and the JNK (c-Jun N-terminal kinase) pathway. In the treatment of autoimmune and inflammatory diseases, researchers have developed biologics such as anti-TNF drugs (e.g., Infliximab, Adalimumab, etc.) to alleviate symptoms and slow disease progression. These drugs work by inhibiting the binding of TNF-α to TNFR1, thereby reducing inflammation. Additionally, TNFR1 is also implicated in tumor development and resistance, making it a potential target in the field of cancer therapy.

More Interesting read related TNFR1: A Multifaceted Molecule in Cancer, Another Promising Therapeutic Target for COVID-19

Popular Product

Recombinant Human Tumor necrosis factor receptor superfamily member 1A(TNFRSF1A),partial (Active) CSB-MP023977HU1

Validated Data

SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ELISA

Activity: Measured by its binding ability in a functional ELISA. Immobilized TNF-α (CSB-YP023955HU) at 5 μg/ml can bind human TNFR1, the EC₅₀ is 7.799-10.90 ng/ml.

ELISA

Activity: Measured by its binding ability in a functional ELISA. Immobilized LTA(CSB-MP013218HU) at 5 μg/ml can bind human TNFR1, the EC₅₀ is 4.409-6.797 ng/ml.