TET2

TET2, part of the TET protein family that includes TET1, TET2, and TET3, is an enzyme that converts 5-methylcytosine to 5-hydroxymethylcytosine, initiating a demethylation process crucial for DNA modification. TET2 enzyme plays a significant role in determining cell fate, differentiation, tumor development, and immune regulation. Abnormalities in TET2 expression or function are linked to a variety of diseases, such as myeloid neoplasms and immune-related disorders. TET2 influences cell proliferation and differentiation by regulating gene expression and DNA methylation, contributing to tumor suppression. Additionally, TET2 impacts the secretion of inflammatory factors and is involved in the modulation of inflammatory responses within the immune system.