SLAMF7

SLAMF7 is a member of the signaling lymphocyte activation molecule family. SLAMF7 can be observed in immune and tumor cells, including natural killer cells and plasma cells. It facilitates signal transduction through its intracellular region containing tyrosine-rich immune receptor switching motifs (ITSMs), with specific tyrosine residues Y281 and Y261 crucial for the activation and inhibition of the SLAMF7 signaling pathway. In the tumor microenvironment, SLAMF7 modulates the anti-tumor effects of immune cells by regulating the activity of NK cells, monocytes/macrophages, and other immune cells. As evidenced by the SLAMF7 monoclonal antibody Elotuzumab, it can activate NK cells and monocytes/macrophages expressing SLAMF7 to participate in the anti-tumor immune response, particularly in multiple myeloma.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SLAMF7 Recombinant Monoclonal Antibody(CSB-RA021369MA1HU)

Validated Data

IHC image of CSB-RA021369MA1HU diluted at 1:200 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.

Overlay Peak curve showing A549 cells surface stained with CSB-RA021369MA1HU (red line) at 1:200. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1µg/1*10⁶cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1µg/1*10⁶cells) used under the same conditions. Acquisition of >10,023 events was performed.

The following SLAMF7 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

SLAMF7 Antibodies

SLAMF7 Proteins

SLAMF7 ELISA Kits

SLAMF7 Antibodies

SLAMF7 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA021369GA01HU	SLAMF7 Antibody	Human	ELISA,WB
CSB-PA021369ESR2HU	SLAMF7 Antibody	Human	ELISA, WB, IHC, IF
CSB-RA021369MA1HU	SLAMF7 Recombinant Monoclonal Antibody	Human	ELISA, IHC, FC
CSB-RA021369MB1HU	SLAMF7 (Elotuzumab Biosimilar) Recombinant Monoclonal Antibody	Human

SLAMF7 Antibodies for Mus musculus (Mouse)

Code	Product Name	Species Reactivity	Application
CSB-PA021369ZA01MO	Slamf7 Antibody	Mus musculus	ELISA, WB (ensure identification of antigen)

SLAMF7 Proteins

SLAMF7 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP021369HU CSB-EP021369HU CSB-BP021369HU CSB-MP021369HU CSB-EP021369HU-B	Recombinant Human SLAM family member 7 (SLAMF7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP021369HU	Recombinant Human SLAM family member 7 (SLAMF7), partial	E.coli
CSB-MP021369HU	Recombinant Human SLAM family member 7 (SLAMF7), partial (Active)	Mammalian cell

SLAMF7 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP021369MO1 CSB-EP021369MO1 CSB-BP021369MO1 CSB-MP021369MO1 CSB-EP021369MO1-B	Recombinant Mouse SLAM family member 7 (Slamf7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP021369MO1	Recombinant Mouse SLAM family member 7 (Slamf7), partial	E.coli

SLAMF7 ELISA Kit

SLAMF7 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-EL021369HU	Human SLAM family member 7(SLAMF7) ELISA kit	serum, plasma, tissue homogenates	19.5 pg/mL

Promotions

Popular Pathways

Apoptosis

Breast Cancer

Autophagy

Hippo Signaling Pathway

Wnt Signaling Pathway

Hippo signaling pathway

TGF-beta signaling pathway

Apoptosis mediated by mitochondria The Overview of Hippo Signaling Pathway The Overview of Autophagy Crosstalk Between Autophagy and Apoptosis The Overview of Wnt Signaling Pathway The Overview of Breast Cancer: Related Signaling Pathways, Therapeutic Targets The overview of TGF-β signaling pathway PI3K-Akt Signaling Pathway and Cancer Apoptosis mediated by endoplasmic reticulum Apoptosisi mediated by death receptor Aesthetic Appreciation of Apoptosis Signal Pathway An Overview of Cell Death: Necrosis and Apoptosis Do You Really Know TGF-β Superfamily?Double-Edged Sword: TGF-β The Overview of PI3-Alt Signaling Pathway How to Inquire and Utilize the Signal Pathway on KEGG LPS/TLR4 Signal Transduction Pathway Epigenetic Histone Modifications Pathway What A Paradoxical TNF Signaling Pathway-Based on Different Receptors The Overview of Fc Receptors- Classification, Related Signaling Pathways and Application

SLAMF7

Popular Product: