SIRPG

SIRPG, also known as Signal regulatory protein gamma, is a single-pass type I membrane protein. It is also commonly called CD172g. This protein has a crucial role in cell - cell signaling. It interacts with CD47 on the cell surface, regulating immune cell responses. The SIRPG - CD47 interaction is involved in the innate immune signaling pathway, which is essential for maintaining immune homeostasis.
Aberrant SIRPG function has been associated with autoimmune diseases and certain types of cancers. In drug development, there is an increasing interest in targeting the SIRPG - CD47 axis. Several potential agents are under pre - clinical investigation, aiming to modulate this pathway for therapeutic benefits in related diseases.