SIRPG Antibody

Code: CSB-PA030198

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Size:

50μg100μg

US$119

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Species Reactivity: Human,Monkey

Raised in: Rabbit

Application: WB, ELISA

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Target Background

Product Details

Uniprot NO.

Q9P1W8

Target Names

SIRPG

Alternative Names

gen like family member B antibody; bA77C3.1 antibody; CD172 antigen-like family member B antibody; CD172g antibody; CD172g antigen antibody; FLJ42230 antibody; RP11-77C3.2 antibody; Signal regulatory protein beta 2 antibody; Signal regulatory protein gamma antibody; Signal-regulatory protein beta-2 antibody; Signal-regulatory protein gamma antibody; SIRP B2 antibody; SIRP beta 2 antibody; SIRP gamma antibody; SIRP-b2 antibody; SIRP-beta-2 antibody; SIRP-gamma antibody; SIRPB2 antibody; SIRPG antibody; SIRPG_HUMAN antibody; SIRPgamma antibody

Raised in

Rabbit

Species Reactivity

Human,Monkey

Immunogen

Synthesized peptide derived from the Internal region of Human CD172g.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Tested Applications

WB, ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.

Gene References into Functions

SIRPgamma in complex with FabOX117 forms a dimer in the crystal. Binding to the Fab fixes the position of domain 1 relative to domains 2/3 exposing a surface which favours formation of a homotypic dimer. PMID:23826770
The independent non-obstructive azoospermia risk alleles are driven by variants in the protein-coding sequence of the two genes, SIRPA and SIRPG. PMID:24162948
a novel member of the signal regulatory protein (SIRP) family- with unique characteristics from both alpha and beta genes- termed SIRPgamma PMID:15294972
CD47 is enriched at endothelial junctions, and its interaction with SIRPgamma is required for human T-cell transendothelial migration PMID:18524990
tumor necrosis factor receptor superfamily, member 14 (TNFRSF14) and signal regulatory protein, gamma (SIRPG) appear to contribute to gender difference in incidence of systemic lupus erythematosus. PMID:19473566

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Tissue Specificity

Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. Mainly present in the

Database Links

HGNC: 15757

UNIGENE: Hs.590883

KEGG: hsa:55423

STRING: 9606.ENSP00000305529

OMIM: 605466

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