PTGIR

PTGIR encodes the prostaglandin I2 receptor, also known as IP receptor, a G protein-coupled receptor primarily activated by prostacyclin. It mediates vasodilation, platelet anti-aggregation, and vascular smooth muscle relaxation via coupling to Gs proteins, increasing intracellular cAMP levels.
PTGIR signaling is critical in cardiovascular homeostasis, linking to pathways like the cAMP/PKA cascade. Dysregulation associates with pulmonary arterial hypertension, thrombosis, and atherosclerosis. Therapeutically, selective agonists are explored for PAH, with beraprost and selexipag targeting IP-mediated vasodilation in clinical use.