PSENEN

Presenilin enhancer gamma-secretase subunit (PSENEN), also known as PEN-2, is an essential regulatory component of the gamma-secretase complex, a multiprotein protease critical for intramembrane cleavage of substrates including amyloid precursor protein (APP) and Notch receptors. As a stabilizing subunit, PSENEN interacts with presenilin (PSEN1/PSEN2), nicastrin, and APH-1 to maintain γ-secretase activity, directly influencing the production of amyloid-β (Aβ) peptides implicated in Alzheimer's disease (AD) pathogenesis. Its catalytic function impacts Notch signaling, a pathway governing cell differentiation and oncogenesis. Pathogenic mutations in PSENEN are associated with familial acne inversa (AI) and rare early-onset AD cases. Drug development targeting γ-secretase has faced challenges due to its pleiotropic roles; however, selective γ-secretase modulators (GSMs) and Notch-sparing inhibitors remain under investigation for AD and cancer. Recent studies explore PSENEN's regulatory role in Aβ42/Aβ40 ratio modulation, a key therapeutic strategy against amyloidosis.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PSENEN Antibody(CSB-PA878932OA01HU)

Validated Data

IHC image of CSB-PA878932OA01HU diluted at 1:400 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA878932OA01HU diluted at 1:400 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

The following PSENEN reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

PSENEN Antibodies

PSENEN Proteins

PSENEN Antibodies

PSENEN Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

Code	Product Name	Species Reactivity	Application
CSB-PA812929XA01DIL	psenen Antibody	Danio rerio (Zebrafish) (Brachydanio rerio)	ELISA, WB (ensure identification of antigen)

PSENEN Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA878932OA01HU	PSENEN Antibody	Human	ELISA, IHC
CSB-PA878932OB01HU	PSENEN Antibody, HRP conjugated	Human	ELISA
CSB-PA878932OC01HU	PSENEN Antibody, FITC conjugated	Human
CSB-PA878932OD01HU	PSENEN Antibody, Biotin conjugated	Human	ELISA
CSB-RA927089A0HU	PSENEN Recombinant Monoclonal Antibody	Human, Mouse, Rat	ELISA, WB, IHC, FC

PSENEN Proteins

PSENEN Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

Code	Product Name	Source
CSB-YP812929DIL CSB-EP812929DIL CSB-BP812929DIL CSB-MP812929DIL CSB-EP812929DIL-B	Recombinant Danio rerio Gamma-secretase subunit PEN-2 (psenen), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PSENEN Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF878932HU	Recombinant Human Gamma-secretase subunit PEN-2 (PSENEN)	in vitro E.coli expression system
CSB-YP878932HU1 CSB-EP878932HU1 CSB-BP878932HU1 CSB-MP878932HU1 CSB-EP878932HU1-B	Recombinant Human Gamma-secretase subunit PEN-2 (PSENEN), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PSENEN Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-CF757686RA	Recombinant Rat Gamma-secretase subunit PEN-2 (Psenen)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP757686RA1 CSB-EP757686RA1 CSB-BP757686RA1 CSB-MP757686RA1 CSB-EP757686RA1-B	Recombinant Rat Gamma-secretase subunit PEN-2 (Psenen), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PSENEN Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-CF688881BO	Recombinant Bovine Gamma-secretase subunit PEN-2 (PSENEN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP688881BO1 CSB-EP688881BO1 CSB-BP688881BO1 CSB-MP688881BO1 CSB-EP688881BO1-B	Recombinant Bovine Gamma-secretase subunit PEN-2 (PSENEN), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PSENEN Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF861450MO	Recombinant Mouse Gamma-secretase subunit PEN-2 (Psenen)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP861450MO1 CSB-EP861450MO1 CSB-BP861450MO1 CSB-MP861450MO1 CSB-EP861450MO1-B	Recombinant Mouse Gamma-secretase subunit PEN-2 (Psenen), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PSENEN Proteins for Dictyostelium discoideum (Slime mold)

Code	Product Name	Source
CSB-CF690507DKK	Recombinant Dictyostelium discoideum Probable gamma-secretase subunit PEN-2 (psenen)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP690507DKK1 CSB-EP690507DKK1 CSB-BP690507DKK1 CSB-MP690507DKK1 CSB-EP690507DKK1-B	Recombinant Dictyostelium discoideum Probable gamma-secretase subunit PEN-2 (psenen), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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PSENEN

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