PDCD1LG2

PDCD1LG2, encoded by the human PDCD1LG2 gene on chromosome 9, is a member of the CD28 family of immune receptors. This protein modulates immunity by engaging with PD-1, thereby inhibiting T cell activation and proliferation, which is crucial for immune tolerance and immune evasion. Found in immune cells like dendritic cells and macrophages, as well as in non-immune cells including tumor cells, PDCD1LG2 helps to regulate immune responses and facilitate tumor immune evasion. Its role in tumor immune evasion highlights its significance in cancer immunotherapy. Moreover, its expression levels correlate with the prognosis of various tumors, marking it as a key biomarker.