PAK2

PAK2, also known as p21-activated kinase 2, is a member of the PAK family of serine/threonine kinases. It is also commonly referred to as gamma-PAK. PAK2 plays a crucial role in regulating cell morphology, motility, and survival. It is activated by small GTPases such as Rac and Cdc42 and participates in the MAPK and PI3K-Akt signaling pathways.
Dysregulation of PAK2 has been associated with various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. In cancer, PAK2 promotes tumor cell invasion and metastasis. Several pharmaceutical companies are currently developing PAK2 inhibitors as potential anti-cancer therapies, aiming to block its activity and halt disease progression.