MUC5AC

MUC5AC encodes the mucin 5AC protein, also commonly known as tracheobronchial mucin. This high - molecular - weight glycoprotein plays a crucial role in the formation and function of the mucus layer in various organs, especially the respiratory and digestive tracts. It acts as a protective barrier against pathogens and irritants. MUC5AC is involved in the Wnt/β - catenin signaling pathway, which regulates its expression.
Altered expression of MUC5AC is associated with several diseases, including chronic obstructive pulmonary disease (COPD), asthma, and gastric cancer. In drug development, targeting MUC5AC has emerged as a potential therapeutic strategy. Some research focuses on developing drugs to inhibit its over - production, but so far, no specific drugs are on the market.