KRT18 encodes the Keratin 18 protein, also commonly known as cytokeratin - 18. Keratin 18 is an important intermediate - filament protein. It forms heterodimers with Keratin 8, providing mechanical stability to cells. This protein is involved in the PI3K - AKT signaling pathway, which regulates cell survival, proliferation, and apoptosis.
Altered expression of KRT18 has been associated with various diseases, including liver diseases and certain cancers. In cancer, elevated levels of KRT18 may indicate a poor prognosis. Regarding drug development, researchers are exploring targeting KRT18 - related pathways to design new therapies, although significant progress towards clinical application is still awaited.
Popular
Product:
KRT18 Antibody(CSB-PA10629A0Rb)
Validated Data
Western blot
All lanes: KRT18 antibody at 2µg/ml
Lane 1: K562 whole cell lysate
Lane 2: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 49 kDa
Observed band size: 49 kDa
Western blot
All lanes: KRT18 antibody at 12µg/ml
Lane 1: A431 whole cell lysate
Lane 2: Hela whole cell lysate
Lane 3: Jurkat whole cell lysate
Lane 4: Zebrafish lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 49 kDa
Observed band size: 49 kDa
Western Blot
Positive WB detected in: K562 whole cell lysate, Hela whole cell lysate
All lanes: KRT18 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 49 kDa
Observed band size: 49 kDa
IHC image of CSB-PA10629A0Rb diluted at 1:800 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescent analysis of HepG2 cells using CSB-PA10629A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Immunocytochemistry analysis of human placenta tissue using CSB-PA10629A0Rb at dilution of 1:100
The following KRT18
reagents supplied by CUSABIO are manufactured under a
strict quality control system. Multiple applications
have been validated and solid technical support is
offered.
KRT18 Proteins
KRT18 Proteins for Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
KRT18 Proteins for Acipenser baerii (Siberian sturgeon)
KRT18 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
KRT18 Proteins for Scyliorhinus stellaris (Nursehound) (Greater spotted dogfish)
KRT18 Proteins for Rattus norvegicus (Rat)
KRT18 Proteins for Homo sapiens (Human)
KRT18 Proteins for Protopterus aethiopicus (Marbled lungfish)
KRT18 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KRT18 Proteins for Mus musculus (Mouse)
