KREMEN1

Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification.

The following KREMEN1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

KREMEN1 Antibodies

KREMEN1 Proteins

KREMEN1 Antibodies

KREMEN1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA850397ESR2HU	KREMEN1 Antibody	Human	ELISA, IHC

KREMEN1 Antibodies for Mus musculus (Mouse)

Code	Product Name	Species Reactivity	Application
CSB-PA860404XA01MO	Kremen1 Antibody	Mus musculus (Mouse)	ELISA, WB (ensure identification of antigen)

KREMEN1 Proteins

KREMEN1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP850397HU CSB-EP850397HU CSB-BP850397HU CSB-MP850397HU CSB-EP850397HU-B	Recombinant Human Kremen protein 1 (KREMEN1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KREMEN1 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP846071RA CSB-EP846071RA CSB-BP846071RA CSB-MP846071RA CSB-EP846071RA-B	Recombinant Rat Kremen protein 1 (Kremen1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KREMEN1 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP860404MO CSB-EP860404MO CSB-BP860404MO CSB-MP860404MO CSB-EP860404MO-B	Recombinant Mouse Kremen protein 1 (Kremen1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KREMEN1 Proteins for Xenopus laevis (African clawed frog)

Code	Product Name	Source
CSB-YP849554XBE CSB-EP849554XBE CSB-BP849554XBE CSB-MP849554XBE CSB-EP849554XBE-B	Recombinant Xenopus laevis Kremen protein 1 (kremen1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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