KREMEN1 Antibody

Code: CSB-PA850397ESR2HU

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Size:

20μl50μl100μl

US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, IHC

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Product Details
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Target Background

Product Details

Uniprot NO.

Q96MU8

Target Names

KREMEN1

Alternative Names

AV002070 antibody; Dickkopf receptor antibody; KREM1_HUMAN antibody; KREMEN antibody; Kremen protein 1 antibody; Kremen protein 1 precursor antibody; Kremen1 antibody; Kringle coding gene marking the eye and the nose antibody; Kringle containing protein marking the eye and the nose antibody; Kringle containing transmembrane protein 1 antibody; Kringle containing transmembrane protein antibody; Kringle domain containing transmembrane protein 1 antibody; Kringle domain-containing transmembrane protein 1 antibody; Kringle-containing protein marking the eye and the nose antibody; KRM1 antibody; RP23 293J16.1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Kremen protein 1 protein (180-380AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol Immunohistochemistry (IHC) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA850397ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA850397ESR2HU at dilution of 1:100

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification.

Gene References into Functions

Structure of the dual-mode Wnt regulator Kremen1 and insight into ternary complex formation with LRP6 and DKK1 have been presented. PMID:27524201
Ectodermal dysplasia including oligodontia is due to homozygosity for KREMEN1 p.F209S (c.626 T>C). PMID:27049303
Kremen1 has a pro-apoptotic activity that is decreased upon Dkk1 binding or by cancer mutations. PMID:26206087
Six Dkk-1, three Sost, one Kremen-1 and 10 LRP-5 polymorphisms were significantly associated with radiological progression of rheumatoid arthritis joint destruction. PMID:23041840
This study demonstrated that a representative tSNP of KREMEN1 might modulate the risk of schizophrenia in the Japanese population. PMID:20153141
Kremen may not be essential for Dkk1-mediated Wnt antagonism and Kremen may only play a role when cells express a high level of LRP5/6 PMID:18502762
Functional characterization of related Kremen proteins in mouse. PMID:12050670