KIR2DS1

KIR2DS1 encodes the Killer cell Immunoglobulin-like Receptor, Two Domains, Short Cytoplasmic Tail 1 protein, also known as CD158h. This protein is expressed on natural killer (NK) cells and a subset of T cells. It binds to specific HLA class I molecules. By interacting with these molecules, KIR2DS1 can activate NK cells, triggering immune responses such as cytokine release and cytotoxicity, which is crucial in the first - line defense against infected and tumor cells.
In terms of clinical relevance, abnormal KIR2DS1 function is linked to autoimmune diseases and certain cancers. Regarding drug development, there is ongoing research to target KIR2DS1. Scientists aim to develop agents that can precisely modulate its activity, either enhancing anti - tumor responses or suppressing over - activated immune responses in autoimmunity.