KCNN4

KCNN4 corresponds to the protein potassium intermediate/small conductance calcium-activated channel subfamily N member 4. It is also commonly known as SK4 or IK1. This protein functions as a calcium-activated potassium channel, which plays a crucial role in regulating cell membrane potential. It is involved in the calcium signaling pathway and participates in processes such as cell proliferation and immune cell activation.
Dysregulation of KCNN4 has been associated with several diseases, including hypertension and certain types of cancer. In drug development, targeting KCNN4 has shown potential as a therapeutic strategy. Some small - molecule inhibitors are under pre - clinical investigation to modulate its activity for treating the related diseases.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

KCNN4 Antibody(CSB-PA012086ESR2HU)

Validated Data

Western blot
All lanes: KCNN4 antibody at 8µg/ml + human serum
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 48 kDa
Observed band size: 48 kDa

Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA012086ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA012086ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA012086ESR2HU at dilution of 1:100

The following KCNN4 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

KCNN4 Antibodies

KCNN4 Proteins

KCNN4 Antibodies

KCNN4 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA012086ESR1HU	KCNN4 Antibody	Human	ELISA, IHC
CSB-PA012086ESR2HU	KCNN4 Antibody	Human	ELISA, WB, IHC
CSB-PA009613	KCNN4 Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA484256	KCNN4 Antibody	Human	ELISA,IHC
CSB-PA980762	KCNN4 Antibody	Human,Mouse	ELISA,WB,IHC

KCNN4 Proteins

KCNN4 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF012086HU	Recombinant Human Intermediate conductance calcium-activated potassium channel protein 4 (KCNN4)	in vitro E.coli expression system
CSB-YP012086HU1 CSB-EP012086HU1 CSB-BP012086HU1 CSB-MP012086HU1 CSB-EP012086HU1-B	Recombinant Human Intermediate conductance calcium-activated potassium channel protein 4 (KCNN4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-MP012086HU	Recombinant Human Intermediate conductance calcium-activated potassium channel protein 4 (KCNN4)-VLPs	Mammalian cell

KCNN4 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-CF886190RA	Recombinant Rat Intermediate conductance calcium-activated potassium channel protein 4 (Kcnn4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP886190RA1 CSB-EP886190RA1 CSB-BP886190RA1 CSB-MP886190RA1 CSB-EP886190RA1-B	Recombinant Rat Intermediate conductance calcium-activated potassium channel protein 4 (Kcnn4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KCNN4 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF012086MO	Recombinant Mouse Intermediate conductance calcium-activated potassium channel protein 4 (Kcnn4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP012086MO1 CSB-EP012086MO1 CSB-BP012086MO1 CSB-MP012086MO1 CSB-EP012086MO1-B	Recombinant Mouse Intermediate conductance calcium-activated potassium channel protein 4 (Kcnn4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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KCNN4

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