ERBB3

ERBB3, receptor tyrosine-protein kinase erbB-3, alias HER3, CD340. ERBB3 protein is a tyrosine kinase receptor belonging to the epidermal growth factor receptor family, which can form heterodimers with other EGFR family members to activate the downstream signaling pathways including PI3K/AKT and MAPK/ERK pathways, which play a critical role in cell proliferation, differentiation and survival.
ERBB3 plays a key role in a variety of normal physiological processes and in tumor development. Overexpression of ERBB3 is closely associated with the development and progression of various cancers (e.g., breast, lung, colorectal, etc.), especially in HER2-positive breast cancer. The interaction of ERBB3 with HER2 is thought to be a promoter of tumor cell proliferation and metastasis. ERBB3 is an important target for cancer therapy, and therapeutic strategies targeting ERBB3 are being widely investigated with the aim of improving patient prognosis and treatment outcomes.