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Recombinant Rat Receptor tyrosine-protein kinase erbB-3 (Erbb3), partial

Recombinant Rat Receptor tyrosine-protein kinase erbB-3 (Erbb3), partial

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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Erbb3

Uniprot NO.

Q62799

Species

Rattus norvegicus (Rat)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

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Target Background

Function

Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.

Gene References into Functions

While no changes occur for ErbB2, ErbB4 and Nrg1, an increase of ErbB3 expression occurs after I/R injury, with and without PostC. PMID:28162790
NTAK/NRG2 secreted from astrocytes bound to ErbB3 on neurons, and promoted neuronal survival and neurite extension in vitro. PMID:27113200
Sox2 promotes satellite glial cell survival through the MAPK pathway via Erbb2-Erbb3 receptors. PMID:26116536
we demonstrated the involvement of ErbB receptors in the regulation of neurite elongation and sodium current induction in PC12 cells PMID:23380500
Binding of L1CAM to erbB enhances its response to neuregulins. PMID:22815787
Alternative transcription initiation results in the formation of a nuclear variant of ErbB3 in rat primary Schwann cells. PMID:21451047
ErbB3 may participate in tooth morphogenesis PMID:12112465
Constitutive activation of the neuregulin-1/ErbB receptor signaling pathway is essential for the proliferation of a neoplastic Schwann cell line. PMID:12838503
Dexamethasone exerts a time-dependent and redundant inhibitory effect on Egfr-mediated proliferative signaling in hepatocytes, targeting ErbB proteins and their positive/negative effectors. PMID:17585012
The erbB3 expression was significantly elevated in well-differentiated carcinoma in normal animals. PMID:17704947
disruption of surface HSP90/HER-2 interaction leads to inhibition of heregulin-induced HER-2-HER-3 heterodimer formation, reduced HER-2 phosphorylation, and impaired downstream kinase signaling. PMID:18056992
Data show that the expression of ErbB3 mRNAs is upregulated after end-to-end and end-to-side nerve regeneration in the rat median nerve model. PMID:18845940