DNMT1

DNMT1, or DNA methyltransferase 1, alias AIM, DNMT, MCMT, CXXC9, HSN1E, ADCADN, m.HsaI, etc. DNMT1 is encoded by the human DNMT1 gene, which is located on chromosome 19.
DNMT1 is an enzyme responsible for transferring methyl groups to newly synthesized DNA strands during DNA replication to maintain the stability of DNA methylation patterns and the transmission of genetic information. Its mechanism of action is mainly through the recognition of hemi-methylated DNA and catalyzing the methylation reaction, which is essential for the maintenance of gene expression patterns and gene silencing.
DNMT1 plays an important role in the regulation of gene expression, embryonic development, cell differentiation and tumorigenesis. Aberrant DNA methylation patterns are associated with a variety of diseases, including cancer and developmental abnormalities.