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Recombinant Chicken DNA (cytosine-5)-methyltransferase 1 (DNMT1), partial

Recombinant Chicken DNA (cytosine-5)-methyltransferase 1 (DNMT1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

DNMT1

Purity

>85% (SDS-PAGE)

Target Names

DNMT1

Uniprot NO.

Q92072

Alternative Names

DNMT1; AIM; DNMTDNA; cytosine-5)-methyltransferase 1; Dnmt1; EC 2.1.1.37; DNA methyltransferase GgaI; DNA MTase GgaI; M.GgaI; MCMT

Species

Gallus gallus (Chicken)

Source

Yeast

Expression Region

1-1537

Target Protein Sequence

MPARSAPPPP ALPPALRRRL RDLERDEDSL SEKETLQEKL RLTRGFLRAE VQRRLSALDA DVRCRELSEE RYLAKVKALL RRELAAENGD AAKLFSRASN GCAGNGEEEW ERGGRGEDGA MEVEEAAASS SSSSSSSSSS SSSSSSSSSL LPAPRARKAR RSRSNGESKK SPASSRVTRS SGRQPTILSV FSKGSTKRKS EEVNGAVKPE VSAEKDEEEE EELEEKEQDE KRIKIETKEG SEIKDEITQV KTSTPAKTTP PKCVDCRQYL DDPDLKFFQG DPDDALEEPE MLTDERLSIF DANEDGFESY EDLPQHKVTS FSVYDKRGHL CPFDTGLIER NIELYFSGAV KPIYDDNPCL DGGVRAKKLG PINAWWITGF DGGEKALIGF TTAFADYILM EPSEEYAPIF ALMQEKIYMS KIVVEFLQNN RDVSYEDLLN KIETTVPPVG LNFNRFTEDS LLRHAQFVVE QVESYDEAGD SDEPPVLITP CMRDLIKLAG VTLGKRRAVR RQAIRHPTRI DKDKGPTKAT TTKLVYLIFD TFFSEQIEKD EREDDKENAM KRRRCGVCEV CQQPECGKCK ACQNMVKFGG SGRSKQACLQ RRCPNLAVRE ADEDEEVDDN IPEMPSPKKM LQGRKKKQNK SRISWVGEPI KSDGKKDFYQ RVCIDSETLE VGDCVSVSPD DPTKPLYLAR VTAMWEDSSG QMFHAHWFCP GSDTVLGATS DPLELFLVDE CEDMQLSYIH GKVNVIYKPP SENWAMEGGL DMEIKMVEDD GRTYFYQMWY DQEYARFETP PRAQPMEDNK YKFCLSCARL DEVRHKEIPK VAEPLDEGDG KMFYAMATKN GVQYRVGDSV YLLPEAFSFS MKPASPAKRP KKEAVDEDLY PEHYRKYSEY IKGSNLDAPD PYRVGRIKEI FCHIRTNGKP NEADIKLRIW KFYRPENTHK SMKATYHADI NLLYWSDEET TVDFCAVQGR CTVVYGEDLT ESIQDYSAGG LDRFYFLEAY NAKTKSFEDP PNHARSSGNK GKGKGKGKGK GKGKSSTTCE QSEPEPTELK LPKLRTLDVF SGCGGLSEGF HQAGVSETLW AIEMWEPAAQ AFRLNNPGTT VFTEDCNVLL KLVMSGEKTN SLGQKLPQKG DVEMLCGGPP CQGFSGMNRF NSRTYSKFKN SLVVSFLSYC DYYRPRFFLL ENVRNFVSFK RSMVLKLTLR CLVRMGYQCT FGVLQAGQYG VAQTRRRAIV LAAAPGEKLP MFPEPLHVFA PRACQLSVVV DDKKFVSNIT RTYSGPFRTI TVRDTMSDLP EIRNGASALE ISYNGEPQSW FQRQIRGSQY QPILRDHICK DMSALVAARM RHIPLAPGSD WRDLPNIEVR LSDGTSTRKL RYTHHEKKNG RSSSGALRGV CSCAEGKPCD PADRQFNTLI PWCLPHTGNR HNHWAGLYGR LEWDGFFSTT VTNPEPMGKQ GRVLHPEQHR VVSVRECARS QGFPDTYRLF GNILDKHRQV GNAVPPPLAK AIGLEIRACV GARMREESGA AVAPPAPEKM EMTAAAD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development. Mediates transcriptional repression by direct binding to HDAC2. Plays a role in promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing.

Gene References into Functions

analysis of expression patterns and miRNA regulation of DNA methyltransferases in chicken primordial germ cells PMID:21559294
analysis of the potential of epigenetic alterations in DNMT1 and DNMT3a, as well as the DNA mutations in DNMT3b, as epigenetic and genetic factors to neoplastic diseases of chickens PMID:18648519

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Subcellular Location

Nucleus.

Protein Families

Class I-like SAM-binding methyltransferase superfamily, C5-methyltransferase family

Tissue Specificity

Testis and lung.

Database Links

UNIGENE: Gga.1206

KEGG: gga:396011

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