CTSL, also known as Cathepsin L, is a lysosomal cysteine protease. It is commonly referred to as CTSL1. This protein plays a crucial role in intracellular protein degradation. It cleaves a wide range of substrates, participating in processes such as antigen presentation and extracellular matrix remodeling. It is involved in the autophagy - lysosomal pathway.
Abnormal expression of CTSL is associated with various diseases, including cancer, where it can promote tumor invasion and metastasis. In neurodegenerative diseases, dysregulation of CTSL may contribute to neuronal damage. Regarding drug development, inhibitors of CTSL are being investigated as potential therapeutic agents for these related diseases.
Popular
Product:
CTSL Recombinant Monoclonal Antibody(CSB-RA006193MA1HU)
Validated Data
IHC image of CSB-RA006193MA1HU diluted at 1:30 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.
IHC image of CSB-RA006193MA1HU diluted at 1:30 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.
Immunofluorescence staining of NIH/3T3 cell with CSB-RA006193MA1HU at 1:10, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L).
CTSL Antibody(CSB-PA11499A0Rb)
Validated Data
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA11499A0Rb at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA11499A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
The following CTSL
reagents supplied by CUSABIO are manufactured under a
strict quality control system. Multiple applications
have been validated and solid technical support is
offered.
CTSL Proteins
CTSL Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
CTSL Proteins for Ovis aries (Sheep)
CTSL Proteins for Gallus gallus (Chicken)
CTSL Proteins for Felis catus (Cat) (Felis silvestris catus)
CTSL Proteins for Homo sapiens (Human)
CTSL Proteins for Rattus norvegicus (Rat)
CTSL Proteins for Sus scrofa (Pig)
CTSL Proteins for Bos taurus (Bovine)
CTSL Proteins for Mus musculus (Mouse)
CTSL Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
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