CD55

CD55, also known as decay-accelerating factor (DAF), is a glycoprotein that plays a crucial role in the regulation of the complement system. It inhibits the formation and accelerates the decay of C3 convertases, thereby protecting host cells from complement-mediated lysis. CD55 is involved in various signaling pathways, including the PI3K-Akt pathway.
Dysregulation of CD55 has been associated with several diseases, such as paroxysmal nocturnal hemoglobinuria (PNH) and age-related macular degeneration (AMD). In drug development, targeting CD55 shows potential for treating these complement-related disorders. Some monoclonal antibodies are under investigation to modulate its function.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CD55 Recombinant Monoclonal Antibody(CSB-RA440943A0HU)

Validated Data

Western Blot
Positive WB detected in: A549 whole cell lysate, 293T whole cell lysate, K562 whole cell lysate
All lanes: CD55 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 42, 49, 40, 57, 60 kDa
Observed band size: 70 kDa

IHC image of CSB-RA440943A0HU diluted at 1:100 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

IHC image of CSB-RA440943A0HU diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Human decay-accelerating factor(DAF/CD55)ELISA Kit(CSB-E05121h)

Validated Data

Code: CSB-E05121h

Size: ,96T,5×96T,10×96T

Sensitivity: 0.09 ng/ml

Detection Range: 0.39 ng/ml- 25ng/ml

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following CD55 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CD55 Antibodies

CD55 Proteins

CD55 ELISA Kits

CD55 Antibodies

CD55 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA005226	CD55 Antibody	Human	WB, ELISA
CSB-PA004945LA01HU	CD55 Antibody	Human	ELISA, IHC, IF
CSB-PA004945LB01HU	CD55 Antibody, HRP conjugated	Human	ELISA
CSB-RA440943A0HU	CD55 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC
CSB-RA004945MB1HU	CD55 (PAT-SC1 Biosimilar) Recombinant Monoclonal Antibody	Human

CD55 Proteins

CD55 Proteins for Pongo pygmaeus (Bornean orangutan)

Code	Product Name	Source
CSB-YP004945EXP CSB-EP004945EXP CSB-BP004945EXP CSB-MP004945EXP CSB-EP004945EXP-B	Recombinant Pongo pygmaeus Complement decay-accelerating factor (CD55)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD55 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP004945HU CSB-EP004945HU CSB-BP004945HU CSB-MP004945HU CSB-EP004945HU-B	Recombinant Human Complement decay-accelerating factor (CD55)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP004945HU1	Recombinant Human Complement decay-accelerating factor (CD55), partial	E.coli

CD55 Proteins for Cavia porcellus (Guinea pig)

Code	Product Name	Source
CSB-YP736710GU CSB-EP736710GU CSB-BP736710GU CSB-MP736710GU CSB-EP736710GU-B	Recombinant Guinea pig Complement decay-accelerating factor (CD55)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD55 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP720250MO CSB-EP720250MO CSB-BP720250MO CSB-MP720250MO CSB-EP720250MO-B	Recombinant Mouse Complement decay-accelerating factor, GPI-anchored (Cd55)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD55 ELISA Kit

CD55 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E05121h	Human decay-accelerating factor(DAF/CD55)ELISA Kit	serum, plasma, tissue homogenates	0.09 ng/ml

Promotions

Popular Pathways

Apoptosis

Breast Cancer

Autophagy

Hippo Signaling Pathway

Wnt Signaling Pathway

Hippo signaling pathway

TGF-beta signaling pathway

Apoptosis mediated by mitochondria The Overview of Hippo Signaling Pathway The Overview of Autophagy Crosstalk Between Autophagy and Apoptosis The Overview of Wnt Signaling Pathway The Overview of Breast Cancer: Related Signaling Pathways, Therapeutic Targets The overview of TGF-β signaling pathway PI3K-Akt Signaling Pathway and Cancer Apoptosis mediated by endoplasmic reticulum Apoptosisi mediated by death receptor Aesthetic Appreciation of Apoptosis Signal Pathway An Overview of Cell Death: Necrosis and Apoptosis Do You Really Know TGF-β Superfamily?Double-Edged Sword: TGF-β The Overview of PI3-Alt Signaling Pathway How to Inquire and Utilize the Signal Pathway on KEGG LPS/TLR4 Signal Transduction Pathway Epigenetic Histone Modifications Pathway What A Paradoxical TNF Signaling Pathway-Based on Different Receptors The Overview of Fc Receptors- Classification, Related Signaling Pathways and Application

CD55

Popular Product: