AGER

AGER, also referred to as RAGE, is a cell-surface-dwelling member of the immunoglobulin superfamily. Acting as a transmembrane signal transduction receptor, AGER engages with various ligands, triggering inflammatory cytokine release through pathways like NF-κ-B. This activation is part of the cell's proliferation, migration, and inflammatory response. AGER's biological ties extend to diabetic complications, neurodegeneration, and cancer, with its expression modulated by inflammation and oxidative stress. It stands as a candidate biomarker for disease severity and prognosis assessment. Therapies targeting AGER, including small molecules or antibody interventions, are on the horizon for novel treatment strategies.