MICA/B (CLN-619 Biosimilar) Recombinant Monoclonal Antibody

Code: CSB-RA56059MB1HU

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Size:

100ug

100ug500ug1mg5mg10mg50mg100mg200mg

US$199

Quantity:

Species Reactivity: Human

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Product Details
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Target Background

Product Details

Uniprot NO.

J9TPG6

Target Names

MICA/B

Alternative Names

MHC Class I chain-related protein; MHC class I polypeptide-related sequence A; MICA; CLN-619

Species Reactivity

Human

Immunogen

Recombinant Human MICA/B protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

0.01M PBS，pH7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Notes

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Lead Time

In stock
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Datasheet & COA

Antibody FAQs

Description

This recombinant monoclonal antibody is a research-grade biosimilar of CLN-619, targeting both MICA (MHC class I chain-related protein A) and MICB (MHC class I chain-related protein B). MICA and MICB are stress-induced surface glycoproteins that function as ligands for the NKG2D receptor on natural killer cells and cytotoxic T cells, serving as danger signals for immune-mediated elimination of transformed or damaged cells. These proteins are upregulated on many human cancers following cellular stress, but tumors evade immune surveillance by proteolytically shedding MICA/B from their surface, releasing soluble forms that correlate with tumor progression and poor prognosis. CLN-619 is a humanized IgG1 antibody that binds to the alpha-3 domain of MICA/B, preventing proteolytic shedding and restoring cell surface expression. This mechanism re-establishes NKG2D-mediated tumor recognition while simultaneously engaging CD16A Fc receptors on immune effector cells, promoting tumor lysis through dual pathways. This biosimilar enables researchers to investigate MICA/B biology, NK cell-mediated tumor immunity, and therapeutic strategies targeting immune evasion mechanisms in preclinical cancer models.