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FZD10 (OTSA-101-DTPA-90Y Biosimilar) Recombinant Monoclonal Antibody

FZD10 (OTSA-101-DTPA-90Y Biosimilar) Recombinant Monoclonal Antibody

Code: CSB-RA891782MB1HU

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Size:

100ug

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US$199

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Species Reactivity: Human

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Target Background

Product Details

Uniprot NO.

Q9ULW2

Alternative Names

OTSA-101-DTPA-90Y research-grade biosimilar ;FZD10 antibody; Frizzled-10 antibody; Fz-10 antibody; hFz10 antibody; FzE7 antibody; CD antigen CD350 antibody

Species Reactivity

Human

Immunogen

Recombinant Human FZD10 protein

Conjugate

Non-conjugated

Clonality

Monoclonal

Buffer

0.01M PBS，pH7.4

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Notes

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Lead Time

3-4 weeks
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Concentration

It differs from different batches. Please contact us to confirm it.

Usage

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Datasheet & COA

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Description

This recombinant monoclonal antibody is a research-grade biosimilar of OTSA-101-DTPA-⁹⁰Y, targeting FZD10 (Frizzled-10)—a 7-transmembrane Wnt signaling receptor in the frizzled family. FZD10 has been reported to be highly overexpressed in synovial sarcoma (SS) while showing little to no expression in most normal adult tissues (with limited exceptions such as placenta), making it an attractive tumor-associated surface target for antigen profiling and target-engagement studies.

OTSA-101-DTPA-⁹⁰Y is a radioimmunoconjugate in which the anti-FZD10 monoclonal antibody OTSA-101 is chelator-conjugated (e.g., DTPA) and labeled with yttrium-90 to deliver β-radiation selectively to FZD10-expressing lesions; related clinical studies have also used ¹¹¹In-labeled OTSA-101 for biodistribution/uptake assessment. This biosimilar provides the antibody component alone, enabling researchers to investigate FZD10 biology, cell-surface binding, and target-mediated internalization/trafficking independent of radiotoxicity, and to support assay development or custom conjugation workflows (e.g., chelator coupling for imaging/therapy research).

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Target Background

Function(From Uniprot)

Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).

Gene References into Functions

there was a strong inverse correlation between nuclear immunostaining scores for beta-catenin expression and expression patterns of FZD10 PMID:19134005
FZD10 transactivation causes the activation of the Dvl-Rac1-JNK pathway and is associated with the development/progression of synovial sarcomas PMID:19137009

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor Fz/Smo family

Tissue Specificity

Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe an

Database Links

HGNC: 4039

UNIGENE: Hs.31664

KEGG: hsa:11211

STRING: 9606.ENSP00000229030

OMIM: 606147

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