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Recombinant Xenopus laevis Fibroblast growth factor receptor 1 (fgfr1)

Recombinant Xenopus laevis Fibroblast growth factor receptor 1 (fgfr1)

Code: CSB-CF008642XBE

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Size:

20μg100μg

US$8421

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Express system: in vitro E.coli expression system

Species: Xenopus laevis (African clawed frog)

Tag Info: N-terminal 10xHis-tagged

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Product Details
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Target Background

Product Details

Target Names

fgfr1

Uniprot NO.

P22182

Alternative Names

fgfr1; fgfra2; Fibroblast growth factor receptor 1; FGFR-1

Species

Xenopus laevis (African clawed frog)

Source

in vitro E.coli expression system

Expression Region

21-812

Target Protein Sequence

ARPPSTLPDEVAPKTKTEVEPYSAQPGDRITLQCRLREDVQSINWVKNGVQLSETNRTRITGEEIQISNAGPEDNGVYACVTNGPSRTYTVLCSVNVSDALPSAEDDDEDDDNSSSEEKAAENSKPNRPLWSHPEKMEKKLHAVPAAKTVKFRCPANGTPTPTLRWLKNNRAFQQDQRIGGYKVRSQTWSLIMDSVVPSDKGNYTCIVENKYGAINHTYQLDVVERSPHRPILQAGLPANTSVTVGTTAEFSCKVYSDPQPHIQWLRHIEINGSRVASDGFPYVEILKTAGVNTSDKDMEVLHLRNVTFEDAGQYTCLAANSIGISHHSAWLTVLKVEDNKPALLASPLQLEIIIYCTGAAFVSAMVVTIIIFKMKHPSKKSDFNSQLAVHKLAKSIPVRRQVTVSGDSSSSMNSGVILVRRLSSSGTPMLSGLSEYELPEDPRWEVARDRLILGKPLGEGCFGQVVMAEAIGLDKEKPNKVTKVAVKMLKSDASEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYTSKGNLREYLRARRPPAMEYCYNPTCVPDQLLSFKDLVSCAYQVARGMDYLASKKCIHRDLAARNVLVTEDNIMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPMEELFKLLKEGHRMDKPTNCTNELYMMMKDCWHAMPSQRPTFNQLVEDLDRILALSSNQEYLDLSMPVNQYSPCFPDTRSSTCSSGEDSMFSHDPLPDEPCLPKYSNGGLKKR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Troubleshooting and FAQs

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Datasheet & COA

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Target Background

Function(From Uniprot)

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by ubiquitination, internalization and degradation.

Subcellular Location

Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle.

Protein Families

Protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily

Database Links

UNIGENE: Xl.34918

KEGG: xla:394418

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