Home
Product
Protein
Transmembrane Proteins
Recombinant Rat Tyrosine-protein phosphatase non-receptor type substrate 1 (Sirpa)

Recombinant Rat Tyrosine-protein phosphatase non-receptor type substrate 1 (Sirpa)

Code: CSB-CF021334RA

Rate （N/A）
Review （0）

Size:

20μg100μg

US$6071

Quantity:

Express system: in vitro E.coli expression system

Species: Rattus norvegicus (Rat)

Tag Info: N-terminal 10xHis-tagged

Send an Inquiry

Start an on-line Chat

Online ordering is currently available for U.S. customers only. For orders outside the U.S., please kindly submit an inquiry or start a chat with us.

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Target Names

Sirpa

Uniprot NO.

P97710

Species

Rattus norvegicus (Rat)

Source

in vitro E.coli expression system

Expression Region

32-509

Target Protein Sequence

KELKVTQADKSVSVAAGDSATLNCTVSSLTPVGPIKWFKGEGQNRSPIYSFIGGEHFPRITNVSDATKRNNMDFSICISNVTPEDAGTYYCVKFQKGIVEPDTEIKSGGGTTLYVLAKPSSPEVSGPDSRGSPGQTVNFTCKSYGFSPRNITLKWLKDGKELSHLETTISSKSNVSYNISSTVSVKLSPEDIHSRVICEVAHVTLEGRPLNGTANFSNIIRVSPTLKITQQPLTPASQVNLTCQVQKFYPKALQLNWLENGNLSRTDKPEHFTDNRDGTYNYTSLFLVNSSAHREDVVFTCQVEHDSQPAITENHTVRAFAHSSSGGSMETIPDNNAYYNWNVFIGVGVACALLVVLLMAALYLLRIKQKKAKGSTSSTRLHEPEKNAREITQIQDTNDINDITYADLNLPKEKKPAPRVPEPNNHTEYASIETGKLPRPEDTLTYADLDMVHLNRAQPTPKPEPSFSEYASVQVQRK
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Troubleshooting and FAQs

Protein FAQs

Datasheet & COA

Please contact us to get it.

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. May play a role in the release of nitric oxide by macrophages.

Gene References into Functions

In the glomeruli of CNS patients carrying mutations in NPHS1, where SD formation is disrupted, the expression of SIRPalpha as well as Neph1 and nephrin was significantly decreased, indicating that SIRPalpha is closely associated with the nephrin complex PMID:22747997
Data suggest that hyperglycemia induces increase in association of SHPS-1 with IAP (integrin-associated protein); this appears to be a generalized response of endothelial cells that contributes to endothelial cell dysfunction. PMID:22193512
Data demonstrate that BIT/SHPS-1 promotes the antiapoptotic effect of BDNF on the low potassium-induced cell death of cerebellar granule neuronss. PMID:21553247
Data show that myelin down-regulates its own phagocytosis through CD47-SIRPalpha interactions. PMID:21401967
CD47-SIRP-alpha interaction may be functionally important in cell-cell communication in the diseased glomerulus. PMID:20554646
BIT is involved in the entrainment of circadian rhythms through the function of NMDARs and non-NMDARs. PMID:12763253
Gp93 was identified as the Ig superfamily member SIRPalpha (also known as SHPS-1, BIT or P84); in rat brain, gp93/SIRPalpha heterogeneity is the result of differential glycosylation (plus phosphorylation), rather than sequence heterogeneity PMID:12807424
Tyrosine phosphorylation level of BIT in the retina is higher in the light period than in the dark period. PMID:14741368
may play a role in the termination of hepatic proliferation during liver regeneration induced by physiological stress or pathological states, such as PH, drugs, toxins PMID:15047126
BIT is involved in the mechanism of neuronal responses to cold exposure in the hypothalamus PMID:15158458
the level of the SHPS-1 mRNA increases in rat skeletal muscle after denervation. Glycosylation of SHPS-1 is N-linked in a muscle-specific manner, and that this is altered upon innervation or denervation. PMID:15858173
SIRPalpha ligation induces macrophage NO production through the cooperative action of JAK/STAT and PI3-K/Rac1/NOX/H(2)O(2) signaling pathways and may function as an activating receptor PMID:16055727
SIRP alpha and SHP-1 potentially mediate the inhibitory effect of elastic laminae on monocyte adhesion. PMID:16159885
These results suggest that SIRPalpha functions in the modulation of axonal growth by extracellular matrix molecules, such as laminin. PMID:16371655
crystallization and X-ray diffraction data collection of the ligand-binding domain of SHPS-1 PMID:16511298
inhibition by SHPS-1 of phagocytosis in macrophages is mediated, at least in part, in a manner independent of the transinteraction between CD47 and SHPS-1 PMID:16920950

Hide All

Subcellular Location

Membrane; Single-pass type I membrane protein.

Tissue Specificity

Highly expressed in brain, spleen, lung, liver and kidney. Detected at lower levels in heart. Highly expressed in alveolar and peritoneal macrophages, and at lower levels in dendritic cells.

Database Links

UNIGENE: Rn.53971

KEGG: rno:25528

STRING: 10116.ENSRNOP00000006408

Promotions