Recombinant Rat Pituitary adenylate cyclase-activating polypeptide type IA receptor (Adcyap1r1)

1. This study demonstrated that the hypothalamic PAC1 mRNA expression level fell after 24 h fasting in male rats, but no such changes were observed in the females. PMID:27181029
2. Compared to the rats in the control group, the rats in the HF group had the expression levels of 12 genes with significant changes, Agrp, Ghrl, and Nr3c1, Apoa4, Cntf, Ghr, IL-1beta, Ins1, Lepr,Sort, Adcyap1r1 and Adrb1. PMID:22715380
3. PACAP-38 cause release of CGRP from trigeminal nucleus caudalis but not from trigeminal ganglia but not via activation of PAC1. PMID:24508136
4. PAC1-R-immunoreactive structures appearing from postnatal day 5 (P5) to P10 in the rat retina, are described.. PMID:24352804
5. Middle meningeal arteries expressed multiple variants of the PAC1 receptor. The expression of PAC1 receptors and the high potency of PACAP to induce MMA vasodilation are consistent with their potential roles in the etiology of migraine. PMID:22766684
6. PACAP causes PAC1/VPAC2 receptor mediated hypertension and sympathoexcitation in normal and hypertensive rats. PMID:22886412
7. PAC1hop, null and hip receptors mediate differential signaling through cyclic AMP and calcium leading to splice variant-specific gene induction in neural cells. PMID:21693142
8. If small molecule PAC-1 receptor antagonists could be identified, they might produce broad-spectrum analgesia in both inflammatory and neuropathic pain states. PMID:18337184
9. inhibitory effect of pituitary adenylate cyclase-activating polypeptide on food intake may be mediated, at least in part, through modulation of neuropeptide Y neurotransmission. PMID:16888209
10. the hop cassette of the PAC1 receptor has a role in coupling to Ca2+ elevation required for PACAP-evoked neurosecretion. PMID:17213203
11. pituitary adenylate-cyclase activating polypeptide and its type 1 receptor, functions as a stimulator of prolactin alone or with thyrotropin releasing hormone in prolactin producing cells PMID:21539889
12. Expression of pituitary adenylate cyclase-activating peptide 1 receptor (PAC1) is significantly increased in the brain of aged rats. PMID:20599818
13. In HEK cells stably overexpressing functional rat PAC1 receptors, PACAP-27 and PACAP-38 strongly stimulated alpha-secretase cleavage of APP. PMID:16401644
14. PAC1-R immunoreactivity was co-localized with afferent dendritic neuronal marker GluR2/3 in nerve fibers passing beneath and lateral to the inner hair cell and in fibers at supranuclear and basal sites on outer hair cells. PMID:16876955
15. The specificity of PAC1 receptor participation in pituitary adenylate cyclase-activating polypeptide-facilitated sex behavior was demonstarted.(PAC1 receptor) PMID:15976009
16. PAC1HOP1 receptor activation coordinates multiple neurotrophic signaling pathways, which involves Akt activation through phosphatidylinositol 3-kinase gamma and vesicle endocytosis for neuronal survival PMID:20093365
17. no age-related differences were observed for pituitary adenylate cyclase activating peptide 1 receptor mRNA in the suprachiasmatic nucleus of young or aged male rats PMID:15344914
18. PAC1(3a) was originally discovered in testes as another potential regulator in rat astrocytes PMID:16888214
19. PAC1-R-positive cells were also seen in the thymic medulla of the rhesus monkey PMID:16888229
20. Novel stable PACAP analogs with potent activity towrds the PAC1 receptor are freported. PMID:18353507

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UNIGENE: Rn.234543

KEGG: rno:24167

STRING: 10116.ENSRNOP00000016175