Recombinant Rat NADPH oxidase 1 (Nox1)

1. Nox1 was able to increase SOD activity, thereby demonstrating its positive effect on the proliferation of MCTPASMCs. PMID:28849167
2. these data demonstrate that altered zinc distribution leading to accumulation of zinc in the mitochondria increases mitochondrial ROS production causing NF-kappaB activation which in turn upregulates Nox1 expression inducing senescence of vascular smooth muscle cells PMID:28363602
3. Curcumin attenuated liver damage through the downregulation of Rac1, Rac1-GTP, and NOX1 as well as reduced oxidative stress in the serum and liver tissue of biliary duct-ligated rats. PMID:28336111
4. Studied the physiology of advanced oxidation protein products (AOPPs) in beta-cell destruction and dysfunction. Found exposure of cells to AOPPs induced an increase in Bax expression, caspase-3 activity, and apoptosis as well as a decrease in Bcl-2 expression. AOPP challenge rapidly increased the production of intracellular superoxide by activation of NADPH oxidases. PMID:28263293
5. Quercetin demonstrated hepatoprotective activity against BDL-induced liver injury through increasing antioxidant capacity of the liver tissue, while preventing the production of Rac1, and NOX1. PMID:28119263
6. NOX1 may be a critical effector of cardiovascular toxicity caused by smoking. PMID:27816504
7. Non-muscle myosin regulatory light chain (nmMLC20) could promote the senescence and dysfunctions of endothelial progenitor cells in pulmonary artery hypertension through up-regulation of NOX in a phosphorylation-dependent manner PMID:26872992
8. NOX1 involvement in aASC cytostasis was reaffirmed when cells that were expanded under normoxic conditions in the presence of a specific NOX1 inhibitor, ML171, demonstrated reduced ROS accumulation, reduced apoptosis and long-term expansion. PMID:25880095
9. Urotensin II-increased reactive oxygen species production via the NADPH oxidase pathway is partially associated with activation of the PI3K/Akt and ERK cascades PMID:26658815
10. Our data suggested that antihypertensive mechanisms of arctigenin were associated with enhanced eNOS phosphorylation and decreased NADPH oxidase-mediated superoxide anion generation. PMID:26585490
11. Activation of the NOX system and subsequent production of ROS are likely responsible for the downregulation of renal tubular Na/K-ATPase expression in early unilateral ureteral obstruction PMID:25997532
12. The activities of pentose phosphate pathway enzymes, NADPH oxidase (Nox), were measured, in brain of neonate rats subjected to a streptozotocin-induced neonatal hyperglycemia. PMID:25682169
13. Established are novel molecular mechanisms underlying oxidative stress-mediated dopaminergic neuronal death in which MMP3 activation is a key upstream event that leads to Nox1 induction and eventual dopaminergic neuronal death. PMID:25536219
14. messenger RNA expressions and protein levels of NADPH oxidase subunits were markedly reduced after IMP treated in SHR. PMID:24973900
15. Cyclic stretch initiates a signal through MEF2B that potentiates Nox1-mediated ROS production and causes VSMC to switch to a synthetic phenotype. PMID:25550204
16. This evidence implies that Nox1-mediated oxidative stress plays an important role in neuronal cell death and cognitive dysfunction in VaD. Nox1 may serve as a potential therapeutic target for VaD. PMID:24294978
17. In conclusion, B. trimera extracts exert antioxidant properties by scavenging ROS and decrease the expression of genes responsible by reactive species production in neutrophils. PMID:24372242
18. These results demonstrate that PKCdelta, NADPH oxidase, and oxidative stress play a causal role in FFA-induced hepatic insulin resistance. PMID:24824652
19. Nox1 mediates H2O2-induced ARPC2 expression. PMID:24152438
20. Upregulation of NOX-1 was found to be involved in cisplatin-induced nephrotoxicity. PMID:24211271
21. Suggest a critical role for NOX1 in the onset of spontaneous pulmonary arterial hypertension by regulating Kv1.5 and intracellular potassium levels. PMID:24233492
22. In dopaminergic neurons exposed to paraquat, protein kinase C(PKC)delta can regulate Nox1 expression. PMID:23827392
23. The expression of NOX1 was upregulated after IL-4 treatment for 4 h, but it was downregulated after 8-24 h. It was suppressesd by amyloid beta or dbcAMP. PMID:22565378
24. NADPH oxidase plays a key role in fructose-induced hepatic oxidative stress production and the mechanism of liver steatosis, suggesting its potential usefulness for the prevention/treatment of Type 2 diabetes mellitus. PMID:22738259
25. dopaminergic neurons are equipped with the Nox1/Rac1 superoxide-generating system. Stress-induced Nox1/Rac1 activation causes oxidative DNA damage and neurodegeneration. PMID:22098189
26. Both ET-1 activation of ET(A)/NADPH oxidase pathway and diminished antioxidants critically contribute to epithelial progenitor cells reduction and dysfunction via increased oxidative stress in salt-sensitive hypertension. PMID:22431579
27. NADPH oxidase and PKC contribute to increased Na transport by the thick ascending limb during type 1 diabetes. PMID:22203737
28. NOX is the main cellular source of the reactive oxygen species generated by hepatic stellate cells in response to leptin stimulation. PMID:21138635
29. Overtraining can activate the NADPH oxidase-mediated overproduction of ROS, leading to increased lipid peroxidation. PMID:21814483
30. An increase of NADPH oxidase-1 in hippocampus follows anxiety-like behavior and adjuvant arthritis. PMID:20970480
31. investigated roles and signal pathways of Nox1 expression involved in hypertrophy of vascular smooth muscle cells induced by aldosterone and revealed that activation of tyrosine kinase Src-ATF1 cascade was essential for aldosterone-Nox1 interactions PMID:21505267
32. NADPH oxidase-dependent formation of reactive oxygen species mediates angiotensin II dependent epithelial-mesenchymal transition and accumulation of extracellular matrix in rat peritoneal mesothelial cells. PMID:21537828
33. Reactive oxygen species generated by flavoprotein NADPH oxidase may be involved in neuronal death in the pilocarpine model of epilepsy. PMID:20732386
34. Expression of Nox1 was increased in vascular smooth muscle cells from SHR. Nox1 regulation by Angiotensin II,but not Endothelin-1,is important in *O(2)(-) formation in VSMCs from SHR. PMID:21419746
35. High NOX1 expression is associated with colon cancers. PMID:20715105
36. NAD(P)H oxidase is an important source of superoxide in pancreatic islets and the activity of NAD(P)H oxidase is involved in the control of insulin secretion by palmitate. PMID:20857410
37. Rac1 induced NADPH oxidase activation, ROS generation and oxidative stress in the hippocampal CA1 region after cerebral ischemia. PMID:20830300
38. Rac1-mediated regulation of phagocyte-like NADPH oxidase contributes to cytokine-mediated mitochondrial dysfunction in the beta-cell. PMID:20943855
39. NOX1 might control autocrine cell growth of liver tumor cells through regulation of the EGFR pathway PMID:20525691
40. NADPH oxidase up-expression is closely associated with hypertension in rats exposed to chronic intermittent hypoxia. PMID:19134410
41. Ang II stimulates TAL O2 production via activation of AT(1) receptors and PKC(alpha)-dependent NADPH oxidase PMID:20448043
42. Data report that the cell invasion activity was augmented in K-Ras-transformed normal rat kidney cells and attenuated by transfection of Nox1 small interference RNAs (siRNAs) into the cells. PMID:20018867
43. The presence of a O(2)(-*)-generating enzyme in close vicinity to the sites of neurotransmitter handling in the nerve fibers suggests the possibility of novel redox-mediated mechanisms in peripheral neurovascular control. PMID:19716351
44. increased HO-1 expression and CO decreases platelet-derived growth factor-stimulated VSMC migration via inhibition of Nox1 enzymatic activity PMID:19875720
45. Nox1 co-localizes with caveolin in punctate patches on the surface & along the cellular margins of vascular smooth muscle cells. Its role may be correlated with its compartamentalization in specific membrane signaling domains. PMID:14670934
46. NAD(P)H oxidase activity is inhibited by HO-1 by down-regulating cytochrome b558 expression via the reduction of heme availability PMID:15123630
47. transactivation of the EGF receptor and the activation of ERK1/2, PI3 kinase, and ATF-1 constitute the signaling pathways involved in the upregulation of NOX1 PMID:15710429
48. iotensin II-related increased expression of NAD(P)H oxidase may play an important role in increased oxidative stress in islets of Type 2 diabetes PMID:15922295
49. NADPH oxidase may mediate ROS-induced apoptosis in pancreatic acinar cells in a Ca(2+)-dependent manner PMID:16085178
50. nos2 expression is downregulated by bilirubin via inhibition of NAD(P)H oxidase PMID:16129699

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UNIGENE: Rn.220465

KEGG: rno:114243

STRING: 10116.ENSRNOP00000065995