Receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.
Gene References into Functions
Study verified that both BLT1 mRNA and BLT1 protein expressions were markedly increased after subarachnoid hemorrhage and elevated BLT1 expressions were mainly found in neurons, microglia and endothelial cells rather than astrocytes. We also demonstrated that there a significant positive correlation between BLT1 and nuclear p65 protein expressions in the same specific time course.PMID:27725151
BLT1 and BLT2 were involved in synovial cell proliferation.PMID:21189570
LTB4 down-regulates airway contraction and inflammation through activation of the hypothalamic-pituitary-adrenal axis via its BLT1 receptor.PMID:20403205
The time-dependent expression of Ltb4r in experimental arthritis was studied.PMID:17481560
FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions.PMID:19657115
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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 1 family
Tissue Specificity
Exclusively expressed in polymorphonuclear leukocytes.