Recombinant Rat Growth hormone receptor (Ghr)

1. receptor crosstalk between growth hormone and insulin signal in rats born small for gestational age with catch-up growth PMID:24963636
2. The growth hormone receptor expression in the brain was lower during fetal period than in adults, while in the pituitary gland, the expression is markedly higher in fetuses, suggesting a yet unknown role of growth hormone in the development of this organ. PMID:21177131
3. Growth hormone receptor mRNA levels decrease in hypothalamus during normal pregnancy while growth hormone expression rises in the pituitary. PMID:20814072
4. Data show that TrCP acts in an early stage of cargo selection: both TrCP silencing and mutation of the ubiquitin-dependent endocytosis motif force the GHR to recycle between endosomes and the plasma membrane. PMID:21195069
5. GH and its receptor have roles in injury-induced neurogenesis PMID:19524466
6. gene expression of GH and GHR mRNA in isolated oocytes and follicular wall cells of pre-antral follicles; localisation of immunoreactive IGF-I, IGFR, GH and GHR proteins in ovarian sections of 10-day-old rats PMID:11964096
7. localization in growth plate PMID:12162495
8. exerts divergent effects on STAT5-mediated transcription depending on its cellular location PMID:12488452
9. findings demonstrate the interaction of cytokine-induced Src homology domain 2 protein(CIS) with the growth hormone receptor in vivo and suggest that CIS may enhance degradation of the receptor by a proteasomal pathway PMID:12586763
10. data suggest that muscle atrophy is associated with a muscle fiber type-specific growth hormone receptor mRNA up-regulation mechanism PMID:12865352
11. The growth plate distribution of IGF-IR and GHR mRNA implies distinct roles for circulating IGF-I vs. paracrine produced IGF-I. PMID:15609625
12. GH receptor in visceral sensory and motor structures is consonant with a role of GH in the regulation of food intake and energy homeostasis. Its presence in the spinal dorsal horn indicates a role for GH in the initial processing of fine afferent input. PMID:15664698
13. The growth hormone(GH)-responsive rat liver cell line CWSV-1 was used to investigate the role of CIS and the proteasome in GH-induced GHR internalization. PMID:16154995
14. In the intrauterine growth restricted rat at one year of age, levels of pituitary GH, GH-R and GHRH-R relative gene expression were increased. PMID:16867182
15. acetaminophen indirectly stimulates spinal (5-HT)1A receptors, thereby increasing transcript and protein levels of low-affinity neurotrophin receptor,(IGF-1) receptor alpha subunit, and growth hormone receptor and reducing the amount of sst3R mRNA PMID:17088403
16. results suggest that the acquisition of mechanisms responsible for the regulation of GH or GHRH-receptor transcription by T3 may be involved in the process of functional development of GH cells PMID:17090972
17. These findings indicate that the heterologous reduction of GHR by insulin occurs via transcriptional downregulation, and the homologous reduction of GHR by GH occurs via a different mechanism. PMID:17658679
18. Insulin signaling via either the PI-3 kinase or MEK/ERK pathway may result in partial reduction of GHR gene expression, whereas signaling via both pathways may be required to achieve the full insulin effect. PMID:18040895

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UNIGENE: Rn.2178

KEGG: rno:25235

STRING: 10116.ENSRNOP00000044119