Recombinant Rat Gap junction beta-2 protein (Gjb2)

1. These results demonstrate that chronic prenatal hypoxia caused hearing impairment, and suggest that promoter region hypermethylation and expression downregulation of Cx26 underlie the mechanism of action PMID:29207085
2. Reduced expression of Connexin26 and its DNA promoter hypermethylation in the inner ear of mimetic aging rats might contribute to the development of presbycusis. PMID:25159847
3. the surface topography of Cx26 hemichannels PMID:25365227
4. Increased expression of connexin 26 protein and mRNA expression in the cochlear lateral wall were detected 3 h after the single injection of gentamicin. PMID:22896926
5. Changes in Cx43 expression following engraftment of neural stem cells to striatal tissue. PMID:20654614
6. T135 and P87 residues are in positions that are important for connexin26 oligomer stability and can affect gap junction gating. PMID:20441744
7. Data show that knowledge of the PTMs of Cx26 will be instrumental in understanding how alterations in the cellular mechanisms of Cx26 channel biogenesis and function lead to losses in auditory function and disfiguring skin disorders. PMID:19775242
8. Data show that mechanical stress of urothelial cells activates in vivo JNK, as a consequence of a regulated expression of IB1/JIP-1, and that urothelial connexin 26 may be directly regulated by the AP-1 complex [connexin 26]. PMID:12064607
9. Data show that connexins are differentially expressed in rat gray matter: Cx26, Cx30 and Cx43 were found only in astrocyte gap junctions; Cx32 was only in oligodendrocytes, and Cx36 was only in neurons [connexin 26] PMID:12064610
10. We report the identification of a novel Cx26 point mutation (439 G-->A) linked to familial, autosomal recessive, sensorineural hearing loss. PMID:14676473
11. Endometrial expression of Cx26 and Cx43 is induced via estrogen and ERalpha during preimplantation but then utilizes an estrogen receptor-independent signaling pathway during embryo implantation and decidualization. PMID:15028626
12. Cx26 forms gap junctions, but not heterotrimeric channels in co-expressing cells. PMID:15128867
13. Aberrant methylation of the Cx26 gene may be involved in the development of lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. PMID:16637067
14. Cx43 and Cx26 collectively co-regulate epidermal differentiation from basal keratinocytes but play a more minimal role in the maintenance of established epidermis PMID:17693411
15. the gap junction subunits connexin 26 (Cx26) and connexin 43 (Cx43) are expressed at the contact points between radial fibres and migrating neurons, and acute downregulation of Cx26 or Cx43 impairs the migration of neurons to the cortical plate PMID:17713529
16. increased CX26 expression is associated with differentiation of keratinocytes PMID:19194037

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UNIGENE: Rn.219269

KEGG: rno:394266

STRING: 10116.ENSRNOP00000011711