Recombinant Rat G-protein coupled estrogen receptor 1 (Gper)

1. The results suggest that GPR30 activation inhibits myocardial fibrosis in diabetic ovariectomy female rats by suppressing cardiac iNOS activity and consequently nitric oxide levels. PMID:30227089
2. These present data have shown for the first time that total mRNA isolation and protein expression from both adipose tissues (abdominal and subcutaneous) of rat in obesity condition yield significative statistical difference among the control versus obese groups, showing that the diet high in carbohydrates modifies the total presence of mRNA and protein level expression of the receptors GPR41, 43 and 120 PMID:29369009
3. This study aims to evaluate the potential role of GPER in coronary circulation in female and male rats. PMID:28733475
4. Results indicate that although administration of a GPR30 antagonist( G-15) reduced overall levels of sexual incentive motivation in male rats, sexual experience counteracted the effects of G-15 on sexual preference. Importantly, neither G-15 treatment nor sexual experience reduced overall sociosexual interest, initial exploratory behavior, or locomotor activity. PMID:28472669
5. GPR30 contributed to the development of BCP by both facilitating excitatory transmission and inhibiting inhibitory transmission in the spinal cord. Our findings provide the new spinal disinhibition and sensitivity mechanisms underlying the development of bone cancer pain. PMID:27608844
6. The cardiac electrogenic sodium/bicarbonate cotransporter (NBCe1) is activated by aldosterone through the G protein-coupled receptor 30 PMID:27249584
7. Gper1 is up regulation regulates vascular remodeling in rats. PMID:27698063
8. ERalpha and GPER1 are localized exclusively to extranuclear sites in the striatum, and approximately 35% of the dendrites and axon terminals labeled for these receptors contain GABA immunoreactivity. PMID:27080432
9. We found that the GPER-1 agonist could significantly decrease immunoglobulin G (IgG) extravasation and increase the levels of tight junctions (occludin and claudin-5) in the CA1 at 24 h of reperfusion after GCI. Further, protein levels of vascular endothelial growth factor A (VEGF-A) was significantly decreased in the ischemic CA1 by G1. Our results suggest that GPER-1 activation reduce tight junctions disruption via inhi PMID:27311857
10. This study aimed to observe the possible protective effect of GPER on early-onset cognitive impairment after a single traumatic brain injury (TBI) and investigate the cellular mechanism underlying its actions. It was found that selective GPER agonist G-1 significantly reduced hippocampal CA1 neuronal loss and improved cognitive impairment in TBI rats. PMID:27908726
11. GPR30 activation reverses adverse effects of ovariectomy on exercise capacity in rats. GPR30 activation prevents Ovariectomy-related reductions in peak twitch in soleus muscle. PMID:27173878
12. Data suggest that expression of Gper1/Gpr30 can be up-regulated by dietary factors; dietary supplementation with flaxseed-derived lignan, secoisolariciresinol diglycoside, up-regulates expression of Gper1/Gpr30 in prostate and may prevent progression of benign prostatic hyperplasia. PMID:27849354
13. prunetin promotes osteoinduction in vivo and the mechanism is defined by signaling through GPR30 resulting in the up-regulation of the key osteogenic gene Runx2 that in turn up-regulates GPR30 PMID:26345541
14. G-protein coupled estrogen receptor (GPER) agonist mimicked the effects of estradiol in enhancing mitochondrial function and biogenesis, whereas GPER inhibitor neutralized them. PMID:26628039
15. Osteoprotective effect of combination therapy of low-dose oestradiol with G15, a specific antagonist of GPR30/GPER in ovariectomy-induced osteoporotic rats. PMID:26181370
16. Activation of GPER results in inhibition of cardiomyocyte apoptosis and cardioprotection. PMID:25936661
17. GPER expression was increased in the aorta of pregnant versus virgin rats. PMID:26408543
18. GPR30 is expressed in rat cardiac fibroblasts. PMID:25893735
19. activation of GPR30 protected bones against osteoporosis in OVX rats and exerted no untoward effect on the uterus PMID:26187146
20. A novel form of synaptic plasticity in field CA3 of hippocampus requires GPER1 activation and BDNF release. PMID:26391661
21. GPR30 mediates the effects of nonylphenol on cardiac l-type calcium channels at lower but not higher concentrations. PMID:26070386
22. Data suggest that oestradiol improves ventricular remodelling by both G-protein coupled oestrogen receptor (GPER)- and membrane-bound oestrogen receptor-alpha-dependent mechanism. PMID:25256868
23. in rat aortic endothelial cells, E2-mediated endothelial effects are predominantly driven by ER and not by GPER. PMID:25150623
24. The results of this study conclude that local GPR30 agonists produce persistent mechanical hyperalgesia in naive female rats. PMID:25280432
25. By acting through GPR41 and 43, butyrate enhanced intracellular free cytosolic Ca2+. Gene-specific silencing of these receptors led to a partial inhibition of the butyrate-induced intracellular Ca2+ rise resulting in a decrease of hGH secretion. PMID:25310566
26. GPR30 decreases cardiac chymase/angiotensin II by inhibiting local mast cell number after estrogen loss. PMID:25712524
27. Our results indicate that activation of GPER-1 lowers testosterone levels in the rat and human testis. PMID:24736568
28. GPER is crucial in modulating glomerular mesangial cell function including extracellular matrix production and migration. PMID:24793639
29. GPR30 participates in mediating estrogen-2 rapid signaling and neuroprotection in the hippocampus following global cerebral ischemia. PMID:24594140
30. 2-methoxyestradiol down-regulation of angiotensin AT1 receptor is dependent on endoplasmic reticulum membrane-associated GRP30. PMID:24262995
31. Activation of GPR30-AC-PKA is a key factor in the alteration of canalicular transporter function and localization induced by E17G. PMID:24115158
32. Activation of G protein-coupled estrogen receptor 1 confers protection after traumatic brain injury. PMID:23659385
33. GPER mediates cardiotropic effects in spontaneously hypertensive rat hearts. PMID:23950890
34. Rat R2C tumor cells express GPER and its activation is associated with decreased cell proliferation and initiation of apoptosis. PMID:23907461
35. GPR30 acts as a rapid transducer in the brain in response to estrogen level changes over the estrous cycle. PMID:22378360
36. Alterations in GPR30 expression and signaling may contribute to vascular dysfunction in aging females and a greater blood pressure in hypertensive males. PMID:23673155
37. Results suggest that estrogen regulates P2X3-mediated peripheral pain by acting on ERalpha and GPR30 receptors expressed in primary afferent neurons, which probably involves the intracellular cAMP-PKA-ERK1/2 pathway. PMID:23610132
38. data support an important role of GPER activation in aldosterone-mediated regulation of endothelial cell growth, as well as in aldosterone's endothelium-mediated regulation of vasoreactivity. PMID:23283935
39. GPR30 can play an important role in mediating the effects of estradiol on spatial learning, possibly by mediating estradiol effects on basal forebrain cholinergic function. PMID:22828404
40. Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3 PMID:23066016
41. GPR30 is necessary for estradiol-induced changes in the 5-HT(1A) receptor signaling pathway and desensitization of 5-HT(1A) receptor signaling. PMID:22265196
42. Data show that the GPR30 agonist G-1 mitigates the adverse effects of oestrogen loss on LV remodelling and the development of diastolic dysfunction in oophorectomized mRen2 Lew rats. PMID:22328091
43. These results indicate that GPR30 is expressed and functional in rat myometrium. GPR30 activation produces depolarization, elevates [Ca2+]i and increases contractility in myometrial cells. PMID:21865584
44. The renoprotective actions of GPR30 may involve attenuation of tubular oxidative stress and activation of megalin-mediated protein reabsorption. PMID:21844484
45. Report expression of GPR30 in the serous and granular epithelial cells of submaxillary gland. PMID:21365775
46. GPR30 is expressed by cholinergic neurons in the basal forebrain, and activation of GPR30 enhances cholinergic function in the hippocampus similar to Estradiol. PMID:20696528
47. these findings would suggest that aldosterone is the predominant mediator of GPR30 activation in vascular cells. PMID:21242460
48. G protein-coupled estrogen receptor 1 may mediate actions important for Sertoli cell function and maintenance of normal testis development and homeostasis PMID:20445128
49. Investigated both mRNA and protein expression of GPER in the rat and human heart. The role of GPER in estrogen protection against ischaemic stress in the rat heart was also assessed. PMID:20596598
50. activation of GPR30 protects cardiac function and decreases myocardial inflammation after global ischemia/reperfusion PMID:20434187

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UNIGENE: Rn.9806

KEGG: rno:171104

STRING: 10116.ENSRNOP00000001732