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Recombinant Rat C-X-C chemokine receptor type 1 (Cxcr1)

Recombinant Rat C-X-C chemokine receptor type 1 (Cxcr1)

Code: CSB-CF304062RA

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Size:

20μg100μg

US$5106

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Express system: in vitro E.coli expression system

Species: Rattus norvegicus (Rat)

Tag Info: N-terminal 10xHis-tagged

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Target Background

Product Details

Target Names

Cxcr1

Uniprot NO.

P70612

Species

Rattus norvegicus (Rat)

Source

in vitro E.coli expression system

Expression Region

1-349

Target Protein Sequence

MAEAEYFIWIAPEGDFEEEFGNITRMLPTGEYFSPCKRVPMTNRQAVVVFYALVFLLSLL GNSLVMLVILYRRRTRSVTDVYVLNLAIADLLFSLTLPFLAVSKWKGWIFGTPLCKMVSL LKEVNFFSGILLLACISVDRYLAIVHATRTLTRKRYLVKFVCMGTWGLSLVLSLPFAIFR QAYKPYRSGTVCYEVLGEATADLRITLRGLSHIFGFLLPLFIMLVCYGLTLRTLFKAHMR QKRRAMWVIFAVVLVFLLCCLPYNLVLLSDTLLGAHLIQDTCERRNNIDQALYITEILGF SHSCLNPVIYAFVGQSFRHEFLKILANLVHKEVLTHHSASFRTSLTTIY
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

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Target Background

Function(From Uniprot)

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system.

Gene References into Functions

N-acetylated proline-glycine-proline induces premature senescence of nucleus pulposus cells through CXCR1-dependent DNA damage and Reactive Oxygen Species production which activates the p53-p21-Rb and p16-Rb pathways. PMID:27769935
may contribute to inflammation in experimental mesangioproliferative glomerulonephritis PMID:23336303
Inhibition of CXCR1 and CXCR2 chemokine receptors improves motor and autonomic neurological outcomes after spinal cord injury. PMID:20877331

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 1 family

Database Links

UNIGENE: Rn.138115

KEGG: rno:54258

STRING: 10116.ENSRNOP00000066188

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