Recombinant Rat C-C chemokine receptor type 5 (Ccr5)

1. The data of this study demonstrated that CCR5 is correlated with up-regulation of the expression of ROCK2 and P-MLC2(Ser19) in the ischaemia cortex PMID:26983670
2. Spinal CCR5 is up-regulated in a model of cancer-induced bone pain. PMID:27848062
3. fatigue upregulates the level of ORM1, which in turn functions as an anti-fatigue protein to enhance muscle endurance via the CCR5 pathway. PMID:26740279
4. Local electroporation of anti-CCR5 siRNA into the left inflamed joints could achieve the silencing of CCR5 gene and alleviate local inflammation just in the knee joint PMID:25300256
5. Expression levels of CCR5 mRNA in the spinal cord are up-regulated after nerve injury. PMID:24589480
6. Blocking CCR5 attenuates, while enhancing CCR5 aggravates myocardial ischemia-reperfusion injury through modulating inflammatory responses in rat heart. PMID:23456481
7. Early and persistent up-regulation of CCL4/CCR5 signaling during epileptogenesis suggests that CCL4 signalling, rather than CCL2 signalling, could have a role in the epileptogenic process. PMID:22353418
8. Decrease in CCR5 in circulating cells strongly protected from excitotoxin-induced seizures, blood-brain barrier leakage, CNS injury, and inflammation, and facilitated neurogenic repair. PMID:20940264
9. CCR5 and CXCR4 are present on the resident testicular macrophages in the interstitial space PMID:11994538
10. Down-regulation of constitutively expressed surface CCR5 levels by interleukin 1-beta in an insulin-producing model system implies receptor internalization for re-utilization or destruction, secretion or both. PMID:12004163
11. CCR5 is phosphorylated at specific sites by protein kinase C and GPCR kinase PMID:12403770
12. Cultured neural progenitor cells from the subventricular zone of adult rat brain express chemokine receptor CCR5. PMID:14732474
13. CCR5 mediates recruitment of both infiltrating macrophages and resident microglia to sites of central nervous system inflammation. PMID:17484785

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UNIGENE: Rn.10736

KEGG: rno:117029

STRING: 10116.ENSRNOP00000066146