Recombinant Rat Alpha-2C adrenergic receptor (Adra2c)

1. new data suggest that alpha2-adrenoceptors play no major role on any indices of female sexual behavior. PMID:25218984
2. the deleterious effect of prenatal malnutrition on neocortical plasticity in the adult progeny is in part consequence of increased neocortical alpha(2C)-adrenoceptor expression PMID:22892388
3. In 6-OHDA-lesioned rats, there was no change in alpha2C adrenoceptor expression in the rostral or caudal striatum in which the highest density of alpha2C mRNA is present. PMID:21562737
4. In aging, the alpha-2C receptor mediated feedback inhibition of epinephrine release from the adrenal medulla is preserved in control rats but compromised in hypertensive rats, resulting in increased epinephrine release. PMID:20691504
5. During the development of hypertension, adrenal alpha(2) -adrenoceptor inhibitory function is conserved, accompanied by reduced noradrenaline release and unchanged adrenaline release in spontaneously hypertensive rats. PMID:21518261
6. Stimulation of adrenergic alpha 2 receptors in the central nucleus of the amygdala attenuates stress-induced reinstatement of nicotine seeking behavior. PMID:20854830
7. Results suggest that changes of beta(2)- and alpha(2C)-adrenergic receptors participate in IL-6-mediated processes in the spleen, especially during chronic stress situations. PMID:20607388
8. In a chronic spinal cord injury rat model, alpha(2)-ARs gene expression is downregulated in the injured segment, but returns to the normal level above and below the injured segment. PMID:19000416
9. intraspinal modulation of the noradrenergic and adrenergic control of the autonomic outflow to the penis by pre- and postsynaptic alpha(2) adrenoceptors. PMID:12379250
10. Alpha 2C-adrenergic receptors are present on axon terminals of spinal interneurons, the majority of them forming axo-dendritic synapses, although a small number of axo-axonic synapses are also found. PMID:12401319
11. Data indicate that most dorsal horn axons possessing alpha 2C-adrenergic receptors are excitatory, adding further support to the suggestion that they originate principally from spinal interneurons. PMID:12591145
12. Alpha 2C-AR terminals are presynaptic to dendrites and somata of lateral spinal nucleus (LSN) neurons and predominantly form asymmetric synapses. PMID:15207357
13. alpha(2A)- and alpha(2C)-adrenoceptors play predominant roles in the regulation of cervical resistance on days 18-21. PMID:19450576

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UNIGENE: Rn.10297

KEGG: rno:24175

STRING: 10116.ENSRNOP00000012322