Recombinant Rat Activin receptor type-1C (Acvr1c)

Code: CSB-CF001259RA

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20μg100μg

US$5996

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Express system: in vitro E.coli expression system

Species: Rattus norvegicus (Rat)

Tag Info: N-terminal 10xHis-tagged

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Target Background

Product Details

Target Names

Acvr1c

Uniprot NO.

P70539

Species

Rattus norvegicus (Rat)

Source

in vitro E.coli expression system

Expression Region

26-493

Target Protein Sequence

LKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVSKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITQHLPTASPDAPRLGPTELTVVITVPVCLLSIAAMLTIWACQDRQCTYRKTKRHNVEEPLAEYSLVNAGKTLKDLIYDATASGSGSGPPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMVKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCDTCAIADLGLAVKHDSIMNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGLVEEYQLPYYDMVPSDPSIEEMRKVVCDQKLRPNLPNQWQSCEALRVMGRIMRECWYANGAARLTALRVKKTISQLCVKEDCKA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

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Target Background

Function(From Uniprot)

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

Gene References into Functions

ALK7 gene silencing has a protective effect on diabetes-induced aortic stiffness, insulin resistance and hyperlipidemia, thus implicating a new potential therapeutic approach to diabetic macrovascular stiffness. PMID:25577243
Data suggest that up-regulation of Nodal expression increases apoptosis of beta cells and is associated with increased Alk7 expression, activation of Smad3 signaling, and down-regulation of apoptosis regulatory proteins. PMID:22550067
ALK7 induces apoptosis through activation of the traditional TGF-beta pathway components PMID:15107418
pancreatic beta cell apoptosis induced by ALK7 activation occurs via the activation of two distinct downstream pathways PMID:16440210
Regulation of nodal/activin receptor-like kinase 7 signaling pathway play a role in the control of ovarian follicular atresia. PMID:16709598

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily

Tissue Specificity

Expressed in brain, kidney, lung, liver, testis, ovary, adrenal gland, heart, prostate, gastrointestinal tract, and spleen. Distributed throughout both adult and embryonic central nervous system and pancreatic islet cells.

Database Links

UNIGENE: Rn.10580

KEGG: rno:245921

STRING: 10116.ENSRNOP00000056047

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