Recombinant Rat ATP-binding cassette sub-family G member 2 (Abcg2)

1. The ROS-mediated increase in the synthesis of MRP-1 and BCRP can play an important role in hyperoxaluria-promoted calcium oxalate urolithiasis by facilitating phosphatidylserine redistribution in renal epithelial cells. PMID:28577929
2. conclusion, MDR1 and BCRP are expressed on apical membranes of the rodent placental SynT-II layer. PMID:27616577
3. Parathryoid hormone down-regulates ABCG2 expression on the plasma membrane to suppress intestinal and renal urate excretion in secondary hyperparathyroidism leading to hyperuricemia. PMID:27988213
4. Insulin significantly increased URAT1 and decreased ABCG2 levels, resulting in increased kidney tubule uric acid reabsorption in streptozotocin-diabetic rats. PMID:28679589
5. unconjugated Bilirubin elevation in Bile Duct Ligated rats impairs the function and expression of breast cancer resistance protein at the Blood-Brain-Barrier, thus contributing to hepatic encephalopathy. PMID:27180978
6. olomoucine II, but not purvalanol A placental passage is affected by p-glycoprotein (ABCB1), breast cancer resistance protein (ABCG2) and multidrug resistance-associated proteins (ABCCs). PMID:26364927
7. Cilostazol inhibits ABCG2 activity increasing donezapil accumulation in the heart and resulting in cardiotoxicity. PMID:26467765
8. Tetronic 904-containing polymeric micelles overcame the overexpression of ABCG2 in the BBB caused by chronic administration of EFV then boosting its penetration into the CNS PMID:26252052
9. In 5/6 nephrectomy model of chronic kidney disease rats exhibited lower excretion of urine uric acid and over-expression of ABCG2 in the ileum. PMID:23584883
10. Data suggest that, with aging, up-regulation of reactive oxygen species derived from xanthine oxidase down-regulates uric acid excretion via down-regulation of active homodimer Bcrp1/Abcg2 which is uric acid efflux transporter in ileal mucosa. PMID:26119820
11. These findings suggest that Bcrp may be involved in the cellular export of select mercuric species PMID:25868844
12. Hepatic BCRP expression and function were oppositely regulated in type 1 and type 2 diabetic models. PMID:24342797
13. Bcrp is localized to the endothelial TJ barrier in microvessels at the interstitium and also the peritubular myoid cells in the testis, but not at the Sertoli cell BTB. Bcrp regulates the configuration of the actin filament bundles at the apical ES. PMID:23403943
14. It may be concluded that BCRP plays an important role in the intestinal efflux of MED-5 and limits the bioavailability after oral administration of MED-15. PMID:23333829
15. Impaired hepatic CYP2C11 and intestinal BCRP expression and activity induced by diabetes contributes to the increased exposure of orally administered glibenclamide. PMID:22393122
16. Report drug metabolizing phenotype of Bcrp knockout rats. PMID:22711747
17. The Abcg2(-/-) rat is a useful model for understanding the role of breast cancer resistance protein in elimination and oral absorption PMID:22869929
18. These findings indicate similar Abcg2 transporter expression, function, and regulation at the blood-spinal cord and blood-brain barriers. PMID:22472606
19. Butyrate (BT) is a BCRP substrate. It is very important in the context of the high levels of BCRP expression in the human colon and the anticarcinogenic and anti-inflammatory role of BT at that level. PMID:21775706
20. It was suggested that the oral absorption of efavirenz is affected by modifications in the ABCG2 intestinal expression contributing to the intra-individual bioavailability variations. PMID:21803024
21. Consistent with protein expression data, no changes in diabetic rats occurred, suggesting an unaltered function of brain bcrp. PMID:21075088
22. investigation of expression and function of BCRP in rat liver; decreased biliary excretion in some genetically modified rat models may be attributed to decreased BCRP expression PMID:21106720
23. Nanomolar concentrations of 17-beta-estradiol (E2) rapidly reduced BCRP1 transport activity in the brain capillaries. PMID:20216549
24. Hepatic oval cells express high levels of MDR1, MRP1 and Bcrp1 genes which may have cytoprotective functions during severe hepatotoxicity. PMID:17669244
25. These results indicate that hepatic oval cells have a phenotype defined by expression of ATP-binding cassette transporter ABCG2/BCRP1, suggesting that oval cells may represent stem cells in the liver. PMID:12819005
26. These results suggest that rat brain capillaries express functional rABCG2 protein and that the transport activity of the protein is up-regulated by astrocyte-derived soluble factor(s) concomitantly with the induction of rABCG2 mRNA PMID:15255930
27. Has an important role in extruding glucuronide and sulfate conjugates formed in enterocytes into the intestinal lumen. PMID:15598971
28. progesterone plays a role in reduction in the expression level of ABCG2 in the placenta with the advance of gestation from the mid stage to the end of gestation PMID:16244436
29. a two-level defensive role of Bcrp in the rat placenta in which the transporter 1) reduces passage of its substrates from mother to fetus but also 2) removes the drug already present in the fetal circulation. PMID:16809480
30. Show low endogenous ABCG2 protein expression, localization and activity in cultures of rat brain microvessel endothelial and glial cells. PMID:17380269
31. we demonstrate for the first time that ABCG2 is a target of Notch signaling, and as such, constitutes one of the genes in the regulatory network of Notch signaling, involved in the maintenance of stem cells. PMID:17635990
32. The rat fetus is protected by Bcrp against potentially detrimental substances from gestational day 15 onwards. PMID:18450391
33. Curcumin may be used to enhance drug exposure when the rate-limiting step of drug absorption and/or tissue distribution is impacted by ABCG2. PMID:18841445

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UNIGENE: Rn.13131

KEGG: rno:312382

STRING: 10116.ENSRNOP00000009546