ALCAM; CD166 antigen; Activated leukocyte cell adhesion molecule; SB-10 antigen; CD antigen CD166; Fragment
Species
Oryctolagus cuniculus (Rabbit)
Source
in vitro E.coli expression system
Expression Region
1-521
Target Protein Sequence
GSPVFIAFRSSTKKSVQYDDVPEYKDRLNLSENYTLSISNARISDEKRFVCMLVTEDDVF EAPTVVKVFKQPSKPEIVSKAPFLETEQLQKLGDCISRDSYPEGNITWYRNGKVLQPLEG AVVIIFKKQMDPVTQLYTMTSSLEYKTTKADIQTPFTCSITYYGPSGQKTVHSEQAVFDI YYPTEQVTIQVLPPKNAIKEGDNITLKCLGNGNPPPEEFFFYLPGQPEGIRSSNTYTLPN VRRNATGNYKCSLIDKKSLIASTAITVHYLDLSLNPXGELTKQIGDSLPVSCTISAIRNA TVVWMKDNIKLRSSPSFSSLQYQDAGNYVCETALQEVEGLKKRESLTLIVEVKPQIKMTK KTDPSGLSKTIICHVEGFPKPAIQWTITGSGSVINQTEESPYINGRYYSKIIISPEENVT LTCAAENQLERTVNSLNVSAISIPEHDEADEISDENREKVNDQAKLIVGIVVGLLLAALV AGVVYWLYMKKSKTASKHVNKDLGNMEENKKLEENNHKTEA
Note: The complete
sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is
translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application,
please explicitly request the full and complete sequence of this protein before ordering.
Protein Length
full length protein
Tag Info
N-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Storage Condition
Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6. Contributes to the formation and maturation of the immunological synapse via its interactions with CD6. Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions. Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation. Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons.
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite.